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Differential metabolic profiles of ginsenosides in artificial gastric juice using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry

Huang, Juan (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.
Gong, Ming Jiong (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.
Bai, Jun Qi (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.
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Su, He (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.
Gong, Lu (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.
Huang, Zhi Hai (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.;Guangdong Prov Hosp Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Peoples R China.
Qiu, Xiao Hui (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.;Guangdong Prov Hosp Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Peoples R China.
Xu, Wen (author)
Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China
Zhang, Jing (author)
Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.
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Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou, Guangdong, Peoples R China.;Guangdong Prov Hosp Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Peoples R China. (creator_code:org_t)
2022-09-12
2022
English.
In: BMC Biomedical chromotography. - : John Wiley & Sons. - 0269-3879 .- 1099-0801. ; 36:12
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Ginsenosides have poor oral bioavailability and undergo rapid biological transformation in the complex gastrointestinal environment. Most studies on the metabolism of ginsenosides have focused on gut bacteria, yet gastric juice remains a nonnegligible factor. Metabolic profiles of ginsenoside monomers formed in artificial gastric juice were separately investigated and qualitatively identified using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MSn). A common pattern of their metabolic pathways was established, showing that ginsenosides were transformed via deglycosylation, hydration, and dehydration pathways. Two major structure types, 20(S), 20(R)-protopanaxatriols and 20(S), 20(R)-protopanaxadiols, basically shared similar transformation pathways and yielded deglycosylated, hydrated, and dehydrated products. Fragmentation patterns of major ginsenosides were also discussed. Consequently, gastric juice, as the primary link in ginsenoside metabolism and as important as the intestinal flora, produces considerable amounts of degraded ginsenosides, providing a partial explanation for the low bioavailabilities of primary ginsenosides.

Subject headings

NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)

Keyword

artificial gastric juice
ginsenosides
LC-MS
metabolic profiles

Publication and Content Type

ref (subject category)
art (subject category)

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