Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.

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Fältnamn	Indikatorer	Metadata
000		03490naa a2200337 4500
001		oai:lup.lub.lu.se:3b1b980f-e0cb-418c-aeb9-f72a83da9f6d
003		SwePub
008		160404s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/16263012 URI
024	7	a https://doi.org/10.1111/j.1460-9568.2010.07265.x2 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Grealish, Shaneu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)med-sge
245	1 0	a Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
264		c 2010-06-01
264	1	b Wiley,c 2010
520		a Abstract Despite the widespread use of mice as models of Parkinson's disease there is a surprising lack of validation and characterisation of unilateral lesion models in mice and the extent of behavioural impairments induced by such lesions. The aim of the present study was to characterise the behavioural deficits observed after injection of 6-hydroxydopamine unilaterally into the substantia nigra, and correlate the behavioural impairments with the extent of damage to the mesostriatal dopaminergic pathway. We found that a recently introduced test for assessment of sensorimotor impairment, the corridor task, was particularly useful in determining lesion severity, and that this test, in combination with standard drug-induced rotation tests, can be used to select animals with profound (>/= 80%) dopaminergic lesions that are stable over time. Based on these data we propose criteria that can be used to predict the extent of lesion, classified as severe, intermediate or mild lesions of the mesostriatal pathway. The correlation of cell loss and striatal innervation with the performance in each test provides a useful tool for the assessment of functional recovery in neurorestoration and cell transplantation studies, and for the evaluation of the in vivo efficacy and performance of stem cell-derived dopamine neuron preparations.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Mattsson, Bengtu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)neur-bma
700	1	a Draxler, Peteru Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ptd
700	1	a Björklund, Andersu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-abj
710	2	a Neurobiologib Forskargrupper vid Lunds universitet4 org
773	0	t European Journal of Neuroscienced : Wileyg Jul 1, s. 2266-2278q Jul 1<2266-2278x 1460-9568x 0953-816X
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/20529122?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1111/j.1460-9568.2010.07265.xy FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/1626301
856	4 8	u https://doi.org/10.1111/j.1460-9568.2010.07265.x

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Av författaren/redakt...: Grealish, Shane; Mattsson, Bengt; Draxler, Peter; Björklund, Ander ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: European Journal ...

Av lärosätet: Lunds universitet

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