Sökning: L773:0953 816X OR L773:1460 9568 > Characterisation of...
Fältnamn | Indikatorer | Metadata |
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000 | 03490naa a2200337 4500 | |
001 | oai:lup.lub.lu.se:3b1b980f-e0cb-418c-aeb9-f72a83da9f6d | |
003 | SwePub | |
008 | 160404s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/16263012 URI |
024 | 7 | a https://doi.org/10.1111/j.1460-9568.2010.07265.x2 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Grealish, Shaneu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)med-sge |
245 | 1 0 | a Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease. |
264 | c 2010-06-01 | |
264 | 1 | b Wiley,c 2010 |
520 | a Abstract Despite the widespread use of mice as models of Parkinson's disease there is a surprising lack of validation and characterisation of unilateral lesion models in mice and the extent of behavioural impairments induced by such lesions. The aim of the present study was to characterise the behavioural deficits observed after injection of 6-hydroxydopamine unilaterally into the substantia nigra, and correlate the behavioural impairments with the extent of damage to the mesostriatal dopaminergic pathway. We found that a recently introduced test for assessment of sensorimotor impairment, the corridor task, was particularly useful in determining lesion severity, and that this test, in combination with standard drug-induced rotation tests, can be used to select animals with profound (>/= 80%) dopaminergic lesions that are stable over time. Based on these data we propose criteria that can be used to predict the extent of lesion, classified as severe, intermediate or mild lesions of the mesostriatal pathway. The correlation of cell loss and striatal innervation with the performance in each test provides a useful tool for the assessment of functional recovery in neurorestoration and cell transplantation studies, and for the evaluation of the in vivo efficacy and performance of stem cell-derived dopamine neuron preparations. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Mattsson, Bengtu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)neur-bma |
700 | 1 | a Draxler, Peteru Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ptd |
700 | 1 | a Björklund, Andersu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-abj |
710 | 2 | a Neurobiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t European Journal of Neuroscienced : Wileyg Jul 1, s. 2266-2278q Jul 1<2266-2278x 1460-9568x 0953-816X |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/20529122?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1111/j.1460-9568.2010.07265.xy FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1626301 |
856 | 4 8 | u https://doi.org/10.1111/j.1460-9568.2010.07265.x |
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