Sökning: L773:1198 743X OR L773:1469 0691 > Viral load and humo...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04424naa a2200577 4500 | |
001 | oai:DiVA.org:umu-74938 | |
003 | SwePub | |
008 | 130702s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:128425009 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-749382 URI |
024 | 7 | a https://doi.org/10.1111/1469-0691.122592 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1284250092 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Pettersson, Lisau Umeå universitet,Virologi4 aut0 (Swepub:umu)liapen96 |
245 | 1 0 | a Viral load and humoral immune response in association with disease severity in Puumala hantavirus-infected patients-implications for treatment |
264 | 1 | b Wiley-Blackwell,c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Hantaviruses are the causative agents of haemorrhagic fever with renal syndrome (HFRS) in Eurasia and of hantavirus cardiopulmonary syndrome (HCPS) in the Americas. The case fatality rate varies between different hantaviruses and can be up to 40%. At present, there is no specific treatment available. The hantavirus pathogenesis is not well understood, but most likely, both virus-mediated and host-mediated mechanisms are involved. The aim of the present study was to investigate the association among Puumala hantavirus (PUUV) viral RNA load, humoral immune response and disease severity in patients with HFRS. We performed a study of 105 PUUV-infected patients that were followed during the acute phase of disease and for up to 1-3 months later. Fifteen of the 105 patients (14%) were classified as having moderate/severe disease. A low PUUV-specific IgG response (p <0.05) and also a higher white blood cell count (p <0.001) were significantly associated with more severe disease. The PUUV RNA was detected in a majority of patient plasma samples up to 9 days after disease onset; however, PUUV RNA load or longevity of viraemia were not significantly associated with disease severity. We conclude that a low specific IgG response was associated with disease severity in patients with HFRS, whereas PUUV RNA load did not seem to affect the severity of HFRS. Our results raise the possibility of passive immunotherapy as a useful treatment for hantavirus-infected patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a age | |
653 | a disease severity | |
653 | a hantavirus | |
653 | a haemorrhagic fever with renal syndrome | |
653 | a humoral immune response | |
653 | a immunoglobulins | |
653 | a neutrophil | |
653 | a Puumala virus | |
653 | a viral load | |
653 | a white blood cell count | |
653 | a mikrobiologi | |
653 | a Microbiology | |
700 | 1 | a Thunberg, Therese,d 1977-u Umeå universitet,Infektionssjukdomar4 aut0 (Swepub:umu)thelin96 |
700 | 1 | a Rocklöv, Joacimu Umeå universitet,Epidemiologi och global hälsa,Arcum4 aut0 (Swepub:umu)joro0003 |
700 | 1 | a Klingström, Jonasu Karolinska Institutet4 aut |
700 | 1 | a Evander, Magnusu Umeå universitet,Virologi,Arcum4 aut0 (Swepub:umu)maev0001 |
700 | 1 | a Ahlm, Clasu Umeå universitet,Infektionssjukdomar,Arcum4 aut0 (Swepub:umu)clah0001 |
710 | 2 | a Umeå universitetb Virologi4 org |
773 | 0 | t Clinical Microbiology and Infectiond : Wiley-Blackwellg 20:3, s. 235-241q 20:3<235-241x 1198-743Xx 1469-0691 |
856 | 4 | u https://doi.org/10.1111/1469-0691.12259y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:635009/FULLTEXT04.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.clinicalmicrobiologyandinfection.com/article/S1198743X14608648/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-74938 |
856 | 4 8 | u https://doi.org/10.1111/1469-0691.12259 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128425009 |
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