L773:1476 5381
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03527naa a2200493 4500 | |
| 001 | oai:DiVA.org:uu-146230 | |
| 003 | SwePub | |
| 008 | 110215s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1462302 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1476-5381.2010.01163.x2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Marklund, Niklasu Uppsala universitet,Neurokirurgi4 aut0 (Swepub:uu)niklmark |
| 245 | 1 0 | a Animal modeling of traumatic brain injury in pre-clinical drug development :b where do we go from here? |
| 264 | c 2012-02-09 | |
| 264 | 1 | b Wiley,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. Survivors of TBI frequently suffer from long term personality changes and deficits in cognitive and motor performance, urgently calling for novel pharmacological treatment options. To date, all clinical trials evaluating neuroprotective compounds have failed in demonstrating clinical efficacy in cohorts of severely injured TBI patients. The purpose of the present review is to describe the utility of animal models of TBI for pre-clinical evaluation of pharmacological compounds. No single animal model can adequately mimic all aspects of human TBI owing to the heterogeneity of clinical TBI. To successfully develop compounds for clinical TBI, a thorough evaluation in several TBI models and injury severities is crucial. Additionally, brain pharmacokinetics and the time window must be carefully evaluated. Although the search for a single-compound, "silver bullet" therapy is ongoing, a combination of drugs targeting various aspects of neuroprotection, neuroinflammation and regeneration may be needed. In summary, finding drugs and prove clinical efficacy in TBI is a major challenge ahead for the research community and the drug industry. For a successful translation of basic science knowledge to the clinic to occur we believe that a further refinement of animal models and functional outcome methods is important. In the clinical setting, improved patient classification, more homogenous patient cohorts in clinical trials, standardized treatment strategies, improved CNS drug delivery systems and monitoring of target drug levels and drug effects is warranted. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 653 | a Traumatic brain injury | |
| 653 | a review | |
| 653 | a neuroprotection | |
| 653 | a magnesium | |
| 653 | a yclosporin | |
| 653 | a glutamate | |
| 653 | a reactive oxygen species | |
| 653 | a inflammation | |
| 653 | a plasticity | |
| 653 | a animal modeling | |
| 653 | a contusion | |
| 653 | a Neurosurgery | |
| 653 | a Neurokirurgi | |
| 653 | a Neurosurgery | |
| 653 | a Neurokirurgi | |
| 700 | 1 | a Hillered, Larsu Uppsala universitet,Neurokirurgi4 aut0 (Swepub:uu)larshill |
| 710 | 2 | a Uppsala universitetb Neurokirurgi4 org |
| 773 | 0 | t British Journal of Pharmacologyd : Wileyg 164:4, s. 1207-1229q 164:4<1207-1229x 0007-1188x 1476-5381 |
| 856 | 4 | u https://europepmc.org/articles/pmc3229758?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-146230 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1476-5381.2010.01163.x |
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