Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing

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Fältnamn	Indikatorer	Metadata
000		02810naa a2200349 4500
001		oai:DiVA.org:su-35088
003		SwePub
008		100114s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-350882 URI
024	7	a https://doi.org/10.1038/nsmb.16522 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fong, Nova4 aut
245	1 0	a Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing
264		c 2009-08-23
264	1	b Nature America Inc,c 2009
338		a print2 rdacarrier
520		a Adenosine-to-inosine (A-to-I) editing has been shown to be an important mechanism that increases protein diversity in the brain of organisms from human to fly. The family of ADAR enzymes converts some adenosines of RNA duplexes to inosines through hydrolytic deamination. The adenosine recognition mechanism is still largely unknown. Here, to investigate it, we analyzed a set of selectively edited substrates with a cluster of edited sites. We used a large set of individual transcripts sequenced by the 454 sequencing technique. On average, we analyzed 570 single transcripts per edited region at four different developmental stages from embryogenesis to adulthood. To our knowledge, this is the first time, large-scale sequencing has been used to determine synchronous editing events. We demonstrate that edited sites are only coupled within specific distances from each other. Furthermore, our results show that the coupled sites of editing are positioned on the same side of a helix, indicating that the three-dimensional structure is key in ADAR enzyme substrate recognition. Finally, we propose that editing by the ADAR enzymes is initiated by their attraction to one principal site in the substrate.
650	7	a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653		a Cell and molecular biology
653		a Cell- och molekylärbiologi
700	1	a Öhman, Marieu Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik4 aut0 (Swepub:su)marohm
700	1	a Bentley, David L4 aut
710	2	a Stockholms universitetb Institutionen för molekylärbiologi och funktionsgenomik4 org
773	0	t Nature Structural & Molecular Biologyd : Nature America Incg 16:9, s. 916-923q 16:9<916-923x 1545-9993x 1545-9985
856	4	u https://europepmc.org/articles/pmc2755206?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-35088
856	4 8	u https://doi.org/10.1038/nsmb.1652

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Av författaren/redakt...: Fong, Nova; Öhman, Marie; Bentley, David L

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NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biokemi och mole ...

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Av lärosätet: Stockholms universitet

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