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  • Emanuelsson, Eric B.Karolinska Institutet,Karolinska Inst, Stockholm, Sweden. (författare)

MRI characterization of skeletal muscle size and fatty infiltration in long--term trained and untrained individuals

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-07-19
  • Wiley,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-315932
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-315932URI
  • https://doi.org/10.14814/phy2.15398DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:235854646URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-322803URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151296643URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20220728
  • QC 20230109
  • This study investigated body composition measures in highly trained and untrained individuals using whole--body magnetic resonance imaging (MRI). Additionally, correlations between these measures and skeletal muscle gene expression were performed. Thirty-six individuals were included: endurance-trained males (ME, n = 8) and females (FE, n = 7), strength-trained males (MS, n = 7), and untrained control males (MC, n = 8) and females (FC, n = 6). MRI scans were performed, and resting M. vastus lateralis (VL) biopsies were subjected to RNA sequencing. Liver fat fraction, visceral adipose tissue volume (VAT), total body fat, and total lean tissue were measured from MRI data. Additionally, cross-sectional area (CSA) and fat signal fraction (FSF) were calculated from Mm. pectoralis, M. erector spinae and M. multifidus combined, Mm. quadriceps, and Mm. triceps surae (TS). Liver fat fraction, VAT, and total body fat relative to body weight were lower in ME and FE compared with corresponding controls. MS had a larger CSA across all four muscle groups and lower FSF in all muscles apart from TS compared with MC. ME had a lower FSF across all muscle groups and a larger CSA in all muscles except TS than MC. FE athletes showed a higher CSA in Mm. pectoralis and Mm. quadriceps and a lower CSA in TS than FC with no CSA differences found in the back muscles investigated. Surprisingly, the only difference in FSF between FE and FC was found in Mm. pectoralis. Lastly, correlations between VL gene expression and VL CSA as well as FSF showed that genes positively correlated with CSA revealed an enrichment of the oxidative phosphorylation and thermogenesis pathways, while the genes positively correlated with FSF showed significant enrichment of the spliceosome pathway. Although limited differences were found with training in females, our study suggests that both regular endurance and resistance training are useful in maintaining muscle mass, reducing adipose tissue deposits, and reducing muscle fat content in males.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Berry, David B.Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA. (författare)
  • Reitzner, Stefan M.Karolinska Institutet,Karolinska Inst, Stockholm, Sweden. (författare)
  • Arif, MuhammadKTH,Systembiologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1vvaean (författare)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England.(Swepub:kth)u1t8kmr6 (författare)
  • Gustafsson, ThomasKarolinska Institutet,Karolinska Inst, Stockholm, Sweden. (författare)
  • Ward, Samuel R.Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA. (författare)
  • Sundberg, Carl JohanKarolinska Institutet,Karolinska Inst, Stockholm, Sweden. (författare)
  • Chapman, Mark A.Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Univ San Diego, Dept Integrated Engn, 5998 Alcala Pk, San Diego, CA 92110 USA. (författare)
  • Karolinska InstitutetKarolinska Inst, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Physiological Reports: Wiley54:9, s. 389-3892051-817X
  • Ingår i:Medicine & Science in Sports & Exercise: Wiley54:9, s. 389-3890195-91311530-0315

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