Sökning: WFRF:(Beulens Joline W.J.) >
Association of Card...
Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension : A Mendelian Randomization Study
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- van Oort, Sabine (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vrije Univ Amsterdam, Amsterdam Univ, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam Cardiovasc Sci Res Inst, Dept Epidemiol, Amsterdam, Netherlands
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- Beulens, Joline W. J. (författare)
- Vrije Univ Amsterdam, Amsterdam Univ, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam Cardiovasc Sci Res Inst, Dept Epidemiol, Amsterdam, Netherlands; Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
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- van Ballegooijen, Adriana J. (författare)
- Vrije Univ Amsterdam, Amsterdam Univ, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam Cardiovasc Sci Res Inst, Dept Epidemiol, Amsterdam, Netherlands; Vrije Univ Amsterdam, Amsterdam Univ, Dept Nephrol, Med Ctr, Amsterdam, Netherlands
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- Grobbee, Diederick E. (författare)
- Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
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(creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 76:6, s. 1971-1979
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Hypertension is a major risk factor for cardiovascular disease and mortality. To identify targets for the prevention of hypertension and its associated disease burden, we used the 2-sample Mendelian randomization method to investigate the causal associations of 18 cardiovascular risk factors and lifestyle behaviors with hypertension. From European-descent genome-wide association studies, we selected genetic variants (P<5×10−8) for type 2 diabetes, fasting glucose, lipids, body mass index, smoking, alcohol and coffee consumption, physical activity, sleep duration, insomnia, and educational level. We extracted the genetic associations with hypertension from 2 European cohorts: the FinnGen Study (15 870 cases and 74 345 controls) and UK Biobank (54 358 cases and 408 652 controls). The inverse-variance weighted method was used as main analysis method. Genetically predicted triglycerides (pooled odds ratio [OR] per 1 SD, 1.17 [1.10–1.25]), body mass index (OR per 1 SD, 1.42 [1.37–1.48]), alcohol dependence (OR, 1.10 [1.06–1.13]), and insomnia (OR, 1.17 [1.13–1.20]) were associated with a higher odds of hypertension. Higher genetically predicted high-density lipoprotein cholesterol (OR per 1 SD, 0.88 [0.83–0.94]) and educational level (OR per 1 SD, 0.56 [0.54–0.59]) were associated with a lower odds of hypertension. Suggestive evidence was obtained for type 2 diabetes, smoking initiation and alcohol consumption with a higher hypertension odds, and longer sleep duration with a lower hypertension odds. This Mendelian randomization study identified high-density lipoprotein cholesterol, triglycerides, body mass index, alcohol dependence, insomnia, and educational level as causal risk factors for hypertension. This implicates that these modifiable risk factors are important targets in the prevention of hypertension.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- education
- hypertension
- lifestyle
- risk factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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