Synthesis, Anti-inflammatory, and Neuroprotective Activity of N-Substituted Phthalimide Derivatives

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(El Seedi H. R.) > Synthesis, Anti-inf...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03803naa a2200433 4500
001		oai:DiVA.org:uu-521846
003		SwePub
008		240129s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5218462 URI
024	7	a https://doi.org/10.1134/S10703632231102572 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bhat, M. A.u King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia.4 aut
245	1 0	a Synthesis, Anti-inflammatory, and Neuroprotective Activity of N-Substituted Phthalimide Derivatives
264	1	b Pleiades Publishing Ltd,c 2023
338		a print2 rdacarrier
520		a A new series of N-substituted phthalimide compounds was synthesized in good yield. All the compounds were characterized by spectroscopic data and were evaluated for their inhibitory activity against the expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and pro-inflammatory proteins in the bacterial lipopolysaccharide (LPS)-induced murine macrophage (RAW 264.7) cells. All the compounds significantly (p <0.05) downregulated the LPS-stimulated COX-2 and iNOS expression from 100% to the ranges of 61.9±5.1–84.5±4.1% and 41.1±5.4–85.3±1.9%) at 10 µM, respectively. Among others, 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N′-[(3,4-dichlorophenyl)methylidene]benzohydrazide displayed the most potent inhibition to the level of (41.1±5.4%) iNOS expression, about half of the potency of dexamethasone (23.0±3.3%). Moreover, the neuroprotective activity of the compounds was assessed against the 6-hydroxydopamine (6-OHDA)-challenged neuroblastoma SH-ST5Y cells, and all compounds exhibited significant (p <0.05) protection with variable potencies. 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N′-[(3,4-dihydroxyphenyl)methylidene]benzohydrazide was found to display more than 70% relative neuroprotection against 6-OHDA-induced cell death with the additional advantage of keeping the highest cell viability index (83.3±4.5%) to the cells.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a N-substituted phthalimides
653		a iNOS
653		a COX-2
653		a anti-inflammatory
653		a neuroprotective
653		a 6-OHDA
700	1	a Ahmed, A. F.u King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia.4 aut
700	1	a Wen, Z.-H.u Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan.4 aut
700	1	a El-Seedi, Hesham R.u Uppsala universitet,Farmakognosi4 aut0 (Swepub:uu)heels173
700	1	a Naglah, A. M.u King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia.4 aut
700	1	a Al-Omar, M. A.u King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia.4 aut
710	2	a King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia.b King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia.4 org
773	0	t Russian journal of general chemistryd : Pleiades Publishing Ltdg 93:11, s. 2935-2940q 93:11<2935-2940x 1070-3632x 1608-3350
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521846
856	4 8	u https://doi.org/10.1134/S1070363223110257

Hitta via bibliotek

Russian journal of general chemistry (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Bhat, M. A.; Ahmed, A. F.; Wen, Z.-H.; El-Seedi, Hesham ...; Naglah, A. M.; Al-Omar, M. A.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmakologi och ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Artiklar i publikationen: Russian journal ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se