Sökning: WFRF:(Fall Katja) > (2010-2014) > Genetic Variation A...
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000 | 05487naa a2200517 4500 | |
001 | oai:DiVA.org:oru-35809 | |
003 | SwePub | |
008 | 140730s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-358092 URI |
024 | 7 | a https://doi.org/10.1002/pros.228202 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Markt, Sarah C.u Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA4 aut |
245 | 1 0 | a Genetic Variation Across C-Reactive Protein and Risk of Prostate Cancer |
264 | c 2014-05-20 | |
264 | 1 | b Wiley-Blackwell,c 2014 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Prostate Cancer FoundationNational Cancer Institute CA42182 CA34944 CA40360 CA141298 CA097193National Heart, Lung, and Blood Institute (Bethesda, MD) HL26490 HL34595 | |
520 | a BACKGROUND. Inflammation has been hypothesized to play an important etiological role in the initiation or progression of prostate cancer. Circulating levels of the systemic inflammation marker C-reactive protein (CRP) have been associated with increased risk of prostate cancer. We investigated the role of genetic variation in CRP and prostate cancer, under the hypothesis that variants may alter risk of disease.METHODS. We undertook a case-control study nested within the prospective Physicians' Health Study among 1,286 men with incident prostate cancer and 1,264 controls. Four single-nucleotide polymorphisms (SNPs) were selected to capture the common genetic variation across CRP (r(2) > 0.8). We used unconditional logistic regression to assess the association between each SNP and risk of prostate cancer. Linear regression models explored associations between each genotype and plasma CRP levels.RESULTS. None of the CRP SNPs were associated with prostate cancer overall. Individuals with one copy of the minor allele (C) in rs1800947 had an increased risk of high-grade prostate cancer (OR: 1.7; 95% CI: 1.1-2.8), and significantly lower mean CRP levels (P-value < 0.001), however, we found no significant association with lethal disease. Mean CRP levels were significantly elevated in men with one or two copies of the minor allele in rs3093075 and rs1417939, but these were unrelated to prostate cancer risk.CONCLUSION. Our findings suggest that SNPs in the CRP gene are not associated with risk of overall or lethal prostate cancer. Polymorphisms in CRP rs1800947 may be associated with higher grade disease, but our results require replication in other cohorts. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a CRP SNPs | |
653 | a prostate cancer | |
653 | a inflammation | |
653 | a Onkologi | |
653 | a Oncology | |
700 | 1 | a Rider, Jennifer R.u Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 aut |
700 | 1 | a Penney, Kathryn L.u Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 aut |
700 | 1 | a Schumacher, Fredrick R.u Keck Sch Med, Dept Prevent Med, Univ So Calif, Los Angeles, USA4 aut |
700 | 1 | a Epstein, Mara M.u Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 aut |
700 | 1 | a Fall, Katja,d 1971-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Epidemiology, Harvard School of Public Health, Boston MA, United States,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)kafl |
700 | 1 | a Sesso, Howard D.u Dept Med, Div Prevent Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 aut |
700 | 1 | a Stampfer, Meir J.u Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 aut |
700 | 1 | a Mucci, Lorelei A.u Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 aut |
710 | 2 | a Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USAb Sch Publ Hlth, Dept Epidemiol, Harvard Univ, Boston, USA; Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, USA; Sch Med, Harvard Univ, Boston, USA4 org |
773 | 0 | t The Prostated : Wiley-Blackwellg 74:10, s. 1034-1042q 74:10<1034-1042x 0270-4137x 1097-0045 |
856 | 4 | u https://europepmc.org/articles/pmc4063346?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35809 |
856 | 4 8 | u https://doi.org/10.1002/pros.22820 |
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