WFRF:(Harris Robert A)
Search: WFRF:(Harris Robert A) > (2010-2014) > Intranasal Delivery...
- 28 of 33
- Previous record
- Next record
- To hitlist
Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis
-
- Fransson, Moa (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Piras, Elena (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Wang, Hao (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
- show more...
- Harris, Robert A (author)
- Leblanc, Katarina (author)
- show less...
- (creator_code:org_t)
- 2014-06-10
- 2014
- English.
- In: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 142:3, s. 431-441
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Treatment with mesenchymal stromal cells (MSC) is currently of interest for a number of diseases including multiple sclerosis (MS). MSCs is well known to target inflamed tissues however, in a therapeutic scenery, systemic administration will lead to few cells reaching the brain. We hypothesized that MSCs may target the brain upon intranasal (i.n) administration and persist in CNS tissue if expressing a CNS-targeting receptor. To demonstrate proof of concept, MSCs were genetically engineered to express a myelin oligodendrocyte glycoprotein (MOG)-specific receptor. Engineered MSCs retained their immunosuppressive capacity, infiltrated into the brain upon i.n. cell administration, and were able to significantly reduce disease symptoms of experimental autoimmune encephalomyelitis (EAE). The mice treated with CNS-targeting MSCs were resistant to further EAE induction whereas non-targeted MSC did not give such persistent effects. Histological analysis revealed increased brain restoration in engineered MSC-treated mice. In conclusion, MSCs can be genetically engineered to target the brain and prolong therapeutic efficacy in an EAE model.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
- 28 of 33
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Fransson, Moa
- Piras, Elena
- Wang, Hao
- Burman, Joachim
- Duprez, Ida
- Harris, Robert A
- show more...
- Leblanc, Katarin ...
- Magnusson, Peetr ...
- Brittebo, Eva
- Loskog, Angelica ...
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Immunology
- Articles in the publication
- Immunology
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
