Influence of low proximal aortic pressure on spinal cord oxygenation in experimental thoracic aortic occlusion

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Fältnamn	Indikatorer	Metadata
000		02846naa a2200313 4500
001		oai:DiVA.org:uu-55003
003		SwePub
008		081017s2001 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-550032 URI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hellberg, Andersu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular Surgery4 aut
245	1 0	a Influence of low proximal aortic pressure on spinal cord oxygenation in experimental thoracic aortic occlusion
264	1	c 2001
338		a print2 rdacarrier
520		a BACKGROUND: To evaluate the effect of low proximal aortic pressure on cerebrospinal fluid (CSF) oxygenation in an experimental thoracic occlusion model. METHODS: In nine pigs, continuous intrathecal pO(2), pCO(2) and pH monitoring was used during double descending thoracic aortic clamping following insertion of an aorto-aortic shunt. In five pigs, the shunt was connected to a citrated bag adjusted at approximately 40-45 cm above the heart for partial exsanguination in order to decrease mean proximal aortic pressure (MPAP) to below 50 mmHg. In four animals, sodium nitroprusside infusion was used for this purpose. RESULTS: Intrathecal pO(2) demonstrated a significant decrease from 4.9+/-2.1 to 2.9+/-2.4 kPa after 10 minutes of aortic cross-clamping. Lowering proximal aortic pressure caused a further significant decrease to 1.2+/-1.7 kPa (p<0.05). In seven pigs (5 in the exsanguination and 2 in the vasodilator group), restoration of mean proximal aortic pressure to 94.0+/-27.7 caused a recovery of CSF pO(2) from 1.2+/-1.9 to 2.8+/-3.0 (p<0.05). CONCLUSIONS: The results of this study demonstrate that MPAP which provides spinal cord perfusion through subclavian-vertebral arteries are crucial for maintenance of spinal cord oxygenation during thoracic aortic occlusion in this pig model.
653		a MEDICINE
653		a MEDICIN
700	1	a Tulga Ulus, A.4 aut
700	1	a Christiansson, Lennartu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care4 aut
700	1	a Bergqvist, Davidu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular Surgery4 aut
700	1	a Thelin, Stefanu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Thoracic Surgery4 aut0 (Swepub:uu)stthe227
700	1	a Karacagil, Sadettinu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Vascular Surgery4 aut
710	2	a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org
773	0	t Journal of Cardiovascular Surgeryg 42:2, s. 227-231q 42:2<227-231x 0021-9509x 1827-191X
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55003

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Av författaren/redakt...: Hellberg, Anders; Tulga Ulus, A.; Christiansson, L ...; Bergqvist, David; Thelin, Stefan; Karacagil, Sadet ...

Artiklar i publikationen: Journal of Cardi ...

Av lärosätet: Uppsala universitet

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