Sökning: WFRF:(Liedberg F.) > European Associatio...
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000 | 05984naa a2200625 4500 | |
001 | oai:lup.lub.lu.se:7aed0f74-456d-4795-824e-18135b5f9ca4 | |
003 | SwePub | |
008 | 230523s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/7aed0f74-456d-4795-824e-18135b5f9ca42 URI |
024 | 7 | a https://doi.org/10.1016/j.eururo.2023.03.0132 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a for2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Rouprêt, Morganu Pitié-Salpêtrière University Hospital4 aut |
245 | 1 0 | a European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma : 2023 Update |
264 | 1 | b Elsevier BV,c 2023 |
520 | a Context: The European Association of Urology (EAU) guidelines panel on upper urinary tract urothelial carcinoma (UTUC) has updated the guidelines to aid clinicians in evidence-based management of UTUC. Objective: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians. Evidence acquisition: The recommendations provided in these guidelines are based on a review of the literature via a systematic search of the PubMed, Ovid, EMBASE, and Cochrane databases. Data were searched using the following keywords: urinary tract cancer, urothelial carcinomas, renal pelvis, ureter, bladder cancer, chemotherapy, ureteroscopy, nephroureterectomy, neoplasm, (neo)adjuvant treatment, instillation, recurrence, risk factors, metastatic, immunotherapy, and survival. The results were assessed by a panel of experts. Evidence synthesis: Even though data are accruing, for many areas there is still insufficient high-level evidence to provide strong recommendations. Patient stratification on the basis of histology and clinical examination (including imaging) and assessment of patients at risk of Lynch syndrome will aid management. Kidney-sparing management should be offered as a primary treatment option to patients with low-risk UTUC and two functional kidneys. In particular, for patients with high-risk or metastatic UTUC, new treatment options have become available. In high-risk UTUC, platinum-based chemotherapy after radical nephroureterectomy, and adjuvant nivolumab for unfit or patients who decline chemotherapy, are options. For metastatic disease, gemcitabine/carboplatin chemotherapy is recommended as first-line treatment for cisplatin-ineligible patients. Patients with PD-1/PD-L1–positive tumours should be offered a checkpoint inhibitor (pembrolizumab or atezolizumab). Conclusions: These guidelines contain information on the management of individual patients according to the current best evidence. Urologists should take into account the specific clinical characteristics of each patient when determining the optimal treatment regimen according to the risk stratification of these tumours. Patient summary: Cancer of the upper urinary tract is rare, but because 60% of these tumours are invasive at diagnosis, timely and appropriate diagnosis is most important. A number of known risk factors exist. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a (Neo)adjuvant therapy | |
653 | a Chemotherapy | |
653 | a Genetic screening | |
653 | a Immunotherapy | |
653 | a Management | |
653 | a Prognostic factors | |
653 | a Renal pelvis | |
653 | a Surgery | |
653 | a Ureter | |
653 | a Urothelial carcinoma | |
700 | 1 | a Seisen, Thomasu Pitié-Salpêtrière University Hospital4 aut |
700 | 1 | a Birtle, Alison J.u University of Manchester4 aut |
700 | 1 | a Capoun, Otakaru Vienna General Hospital / University Hospital Vienna,General University Hospital in Prague4 aut |
700 | 1 | a Compérat, Eva M.u Vienna General Hospital / University Hospital Vienna,Hopital Tenon,General University Hospital in Prague4 aut |
700 | 1 | a Dominguez-Escrig, José L.u Instituto Valenciano de Oncologia4 aut |
700 | 1 | a Gürses Andersson, Irene4 aut |
700 | 1 | a Liedberg, Fredriku Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)urok-fli |
700 | 1 | a Mariappan, Paramananthanu Western General Hospital4 aut |
700 | 1 | a Hugh Mostafid, A.4 aut |
700 | 1 | a Pradere, Benjaminu Medical University of Vienna4 aut |
700 | 1 | a van Rhijn, Bas W.G.u Antoni Van Leeuwenhoek Hospital,University of Regensburg4 aut |
700 | 1 | a Shariat, Shahrokh F.u University Hospital Motol,Vienna General Hospital / University Hospital Vienna4 aut |
700 | 1 | a Rai, Bhavan P.u Freeman Hospital4 aut |
700 | 1 | a Soria, Francescou University of Turin4 aut |
700 | 1 | a Soukup, Viktoru General University Hospital in Prague,Vienna General Hospital / University Hospital Vienna4 aut |
700 | 1 | a Wood, Robbert G.4 aut |
700 | 1 | a Xylinas, Evanguelos N.u Université Paris Cité4 aut |
700 | 1 | a Masson-Lecomte, Alexandrau Université Paris Cité4 aut |
700 | 1 | a Gontero, Paolou University of Turin4 aut |
710 | 2 | a Pitié-Salpêtrière University Hospitalb University of Manchester4 org |
773 | 0 | t European Urologyd : Elsevier BVg 84:1, s. 49-64q 84:1<49-64x 0302-2838 |
856 | 4 | u http://dx.doi.org/10.1016/j.eururo.2023.03.013y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/7aed0f74-456d-4795-824e-18135b5f9ca4 |
856 | 4 8 | u https://doi.org/10.1016/j.eururo.2023.03.013 |
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