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Sökning: WFRF:(Lopez Sendon J.) > Non-adherence to iv...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004018naa a2200625 4500
001oai:gup.ub.gu.se/239644
003SwePub
008240528s2016 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2396442 URI
0247 a https://doi.org/10.1002/ejhf.4932 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bohm, M.4 aut
2451 0a Non-adherence to ivabradine and placebo and outcomes in chronic heart failure: an analysis from SHIFT
264 c 2016-03-08
264 1b Wiley,c 2016
520 a AimsIn heart failure, non-adherence increases events; in turn, the effect of hospitalization on adherence is incompletely understood. We explored the relationship of non-adherence to outcomes, hospitalizations with non-adherence, and the influence of non-adherence on treatment effects of heart rate lowering with ivabradine. Methods and resultsIn the randomized, controlled Systolic Heart failure treatment with the If-inhibitor ivabradine Trial (SHIFT), we studied the effect of non-adherence (n = 1287) compared with adherence (n=5204) on cardiovascular outcomes. After adjustment, non-adherence was associated with the primary composite endpoint of cardiovascular death and heart failure hospitalization (hazard ratio 3.47, 95% confidence interval 2.91-4.13, P < 0.0001). No interaction with the treatment groups of placebo or ivabradine (P for interaction 0.54) occurred. Similar results for cardiovascular death and heart failure hospitalization, as well as for cardiovascular hospitalization, heart failure death, and total death were observed. The effect of ivabradine was maintained in patients being adherent or becoming non-adherent during the trial (P for interaction=0.54). Patients with a previous hospitalization were more likely to become non-adherent thereafter. ConclusionsNon-adherence identifies a group at particularly high cardiovascular event risk independent of treatment allocation. Non-adherent patients in the ivabradine group maintain a treatment benefit. Patients with previous hospitalizations are more likely to become non-adherent and represent a group of particularly high-risk patients in whom special attention to stimulate adherence may be valuable.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Heart failure
653 a SHIFT
653 a Heart rate
653 a Adherence
653 a Cardiovascular hospitalizations
653 a evidence-based pharmacotherapy
653 a medication adherence
653 a follow-up
653 a cardiovascular outcomes
653 a myocardial-infarction
653 a drug adherence
653 a older
653 a patients
653 a double-blind
653 a mortality
653 a association
653 a Cardiovascular System & Cardiology
7001 a Lloyd, S. M.4 aut
7001 a Ford, I.4 aut
7001 a Borer, J. S.4 aut
7001 a Ewen, S.4 aut
7001 a Laufs, U.4 aut
7001 a Mahfoud, F.4 aut
7001 a Lopez-Sendon, J.4 aut
7001 a Ponikowski, P.4 aut
7001 a Tavazzi, L.4 aut
7001 a Swedberg, Karl,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsweka
7001 a Komajda, M.4 aut
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
7730 t European Journal of Heart Failured : Wileyg 18:6, s. 672-683q 18:6<672-683x 1388-9842x 1879-0844
8564 u http://eprints.gla.ac.uk/121621/1/121621.pdf
8564 8u https://gup.ub.gu.se/publication/239644
8564 8u https://doi.org/10.1002/ejhf.493

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