Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Mai H.) > Association of the ...

Details
MARC

Engel, C. (author)

Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

Article/chapterEnglish2010

Publisher, publication year, extent ...

American Association for Cancer Research,2010
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:hj-39676
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39676URI
https://doi.org/10.1158/1055-9965.EPI-10-0517DOI
https://lup.lub.lu.se/record/1710693URI
https://gup.ub.gu.se/publication/140258URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121563982URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135364URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The Swedish BRCA1 and BRCA2 study (SWE-BRCA) SWE-BRCA collaborators: Per Karlsson, Margareta Nordling, Annika Bergman, and Zakaria Einbeigi, Gothenburg, Sahlgrenska University Hospital; Marie Stenmark-Askmalm and Sigrun Liedgren, Linkoping University Hospital; Ake Borg, Niklas Loman, Hakan Olsson, Ulf Kristoffersson, Helena Jernstrom, Katja Harbst, and Karin Henriksson, Lund University Hospital; Annika Lindblom, Brita Arver, Anna von Wachenfeldt, Annelie Liljegren, Gisela Barbany-Bustinza, and Johanna Rantala, Stockholm, Karolinska University Hospital; Beatrice Malmer, Henrik Gronberg, Eva-Lena Stattin, and Monica Emanuelsson, Umea University Hospital; Hans Ehrencrona, Richard Rosenquist Brandell, and Niklas Dahl, Uppsala University Hospital. We thank the Swedish Cancer Society.
Background: The genes caspase-8 (CASP8) and caspase-10 (CASP10) functionally cooperate and play a key role in the initiation of apoptosis. Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer. Previous case-control studies have indicated that the polymorphisms CASP8 D302H and CASP10 V410I are associated with a reduced risk of breast cancer in the general population.Methods: To evaluate whether the CASP8 D302H (CASP10 V410I) polymorphisms modify breast or ovarian cancer risk in BRCA1 and BRCA2 mutation carriers, we analyzed 7,353 (7,227) subjects of white European origin provided by 19 (18) study groups that participate in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A weighted cohort approach was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; Ptrend = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; Ptrend = 0.004) for BRCA1 but not for BRCA2 mutation carriers. The CASP10 V410I polymorphism was not associated with breast or ovarian cancer risk for BRCA1 or BRCA2 mutation carriers.Conclusions: CASP8 D302H decreases breast and ovarian cancer risk for BRCA1 mutation carriers but not for BRCA2 mutation carriers.Impact: The combined application of these and other recently identified genetic riskmodifiers could in the future allow better individual risk calculation and could aid in the individualized counseling and decision making with respect to preventive options in BRCA1 mutation carriers.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
BRCA1 protein
BRCA2 protein
caspase 10
caspase 8
adult
allele
article
breast cancer
cancer risk
DNA polymorphism
female
genetic variability
human
major clinical study
ovary cancer
priority journal
Breast Neoplasms
Genes
BRCA1
Genes
BRCA2
Genetic Predisposition to Disease
Genotype
Humans
Mutation
Ovarian Neoplasms
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
Risk Factors
Breast Neoplasms
enzymology
genetics
Caspase 10
Caspase 8
Female
Genes
BRCA1
BRCA2
Genetic Predisposition to Disease
Genotype
Humans
Mutation
Ovarian Neoplasms
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
Risk Factors
MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

Versmold, B. (author)
Wappenschmidt, B. (author)
Simard, J. (author)
Easton, D. F. (author)
Peock, S. (author)
Cook, M. (author)
Oliver, C. (author)
Frost, D. (author)
Mayes, R. (author)
Evans, D. G. (author)
Eeles, R. (author)
Paterson, J. (author)
Brewer, C. (author)
McGuffog, L. (author)
Antoniou, A. C. (author)
Stoppa-Lyonnet, D. (author)
Sinilnikova, O. M. (author)
Barjhoux, L. (author)
Frenay, M. (author)
Michel, C. (author)
Leroux, D. (author)
Dreyfus, H. (author)
Toulas, C. (author)
Gladieff, L. (author)
Uhrhammer, N. (author)
Bignon, Y. -J (author)
Meindl, A. (author)
Arnold, N. (author)
Varon-Mateeva, R. (author)
Niederacher, D. (author)
Preisler-Adams, S. (author)
Kast, K. (author)
Deissler, H. (author)
Sutter, C. (author)
Gadzicki, D. (author)
Chenevix-Trench, G. (author)
Bergman, Annika,1972Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:hj)berann (author)
Chen, X. (author)
Beesley, J. (author)
Olsson, HåkanLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol (author)
Kristoffersson, UlfLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-ukr (author)
Ehrencrona, HansUppsala universitet,Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Institutionen för genetik och patologi(Swepub:lu)med-hen (author)
Liljegren, A.Karolinska Institutet (author)
Van Der Luijt, R. B. (author)
Van Os, T. A. (author)
Van Leeuwen, F. E. (author)
Domchek, S. M. (author)
Rebbeck, T. R. (author)
Nathanson, K. L. (author)
Osorio, A. (author)
Ramón Y Cajal, T. (author)
Konstantopoulou, I. (author)
Benítez, J. (author)
Friedman, E. (author)
Kaufman, B. (author)
Laitman, Y. (author)
Mai, P. L. (author)
Greene, M. H. (author)
Nevanlinna, H. (author)
Aittomäki, K. (author)
Szabo, C. I. (author)
Caldes, T. (author)
Couch, F. J. (author)
Andrulis, I. L. (author)
Godwin, A. K. (author)
Hamann, U. (author)
Schmutzler, R. K. (author)
Bergman, AnnikaSahlgrenska University Hospital, Gothenburg, Sweden(Swepub:hj)berann (contributor)
Nordling, Margareta,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics(Swepub:gu)xnmarx (author)
Einbeigi, Zakaria,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xeinza (author)
Karlsson, Per,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xkperd (author)
Spurdle, Amanda B. (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik (creator_code:org_t)

Related titles

In:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research19:11, s. 2859-28681055-99651538-7755

Internet link

Find in a library

Cancer Epidemiology, Biomarkers and Prevention (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Engel, C.; Versmold, B.; Wappenschmidt, B ...; Simard, J.; Easton, D. F.; Peock, S.; show more...; Cook, M.; Oliver, C.; Frost, D.; Mayes, R.; Evans, D. G.; Eeles, R.; Paterson, J.; Brewer, C.; McGuffog, L.; Antoniou, A. C.; Stoppa-Lyonnet, ...; Sinilnikova, O. ...; Barjhoux, L.; Frenay, M.; Michel, C.; Leroux, D.; Dreyfus, H.; Toulas, C.; Gladieff, L.; Uhrhammer, N.; Bignon, Y. -J; Meindl, A.; Arnold, N.; Varon-Mateeva, R ...; Niederacher, D.; Preisler-Adams, ...; Kast, K.; Deissler, H.; Sutter, C.; Gadzicki, D.; Chenevix-Trench, ...; Bergman, Annika, ...; Chen, X.; Beesley, J.; Olsson, Håkan; Kristoffersson, ...; Ehrencrona, Hans; Liljegren, A.; Van Der Luijt, R ...; Van Os, T. A.; Van Leeuwen, F. ...; Domchek, S. M.; Rebbeck, T. R.; Nathanson, K. L.; Osorio, A.; Ramón Y Cajal, T ...; Konstantopoulou, ...; Benítez, J.; Friedman, E.; Kaufman, B.; Laitman, Y.; Mai, P. L.; Greene, M. H.; Nevanlinna, H.; Aittomäki, K.; Szabo, C. I.; Caldes, T.; Couch, F. J.; Andrulis, I. L.; Godwin, A. K.; Hamann, U.; Schmutzler, R. K ...; Bergman, Annika; Nordling, Margar ...; Einbeigi, Zakari ...; Karlsson, Per, 1 ...; Spurdle, Amanda ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

Articles in the publication: Cancer Epidemiol ...

By the university: Jönköping University; Lund University; University of Gothenburg; Karolinska Institutet; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se