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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04380naa a2200697 4500 | |
| 001 | oai:gup.ub.gu.se/311618 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3116182 URI |
| 024 | 7 | a https://doi.org/10.1007/s00223-021-00924-22 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cronin, O.4 aut |
| 245 | 1 0 | a Role of the Microbiome in Regulating Bone Metabolism and Susceptibility to Osteoporosis |
| 264 | c 2021-12-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a The human microbiota functions at the interface between diet, medication-use, lifestyle, host immune development and health. It is therefore closely aligned with many of the recognised modifiable factors that influence bone mass accrual in the young, and bone maintenance and skeletal decline in older populations. While understanding of the relationship between micro-organisms and bone health is still in its infancy, two decades of broader microbiome research and discovery supports a role of the human gut microbiome in the regulation of bone metabolism and pathogenesis of osteoporosis as well as its prevention and treatment. Pre-clinical research has demonstrated biological interactions between the microbiome and bone metabolism. Furthermore, observational studies and randomized clinical trials have indicated that therapeutic manipulation of the microbiota by oral administration of probiotics may influence bone turnover and prevent bone loss in humans. In this paper, we summarize the content, discussion and conclusions of a workshop held by the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society in October, 2020. We provide a detailed review of the literature examining the relationship between the microbiota and bone health in animal models and in humans, as well as formulating the agenda for key research priorities required to advance this field. We also underscore the potential pitfalls in this research field that should be avoided and provide methodological recommendations to facilitate bridging the gap from promising concept to a potential cause and intervention target for osteoporosis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Osteoporosis | |
| 653 | a Microbiome | |
| 653 | a Immunology | |
| 653 | a Probiotics | |
| 653 | a gut microbiota | |
| 653 | a postmenopausal women | |
| 653 | a double-blind | |
| 653 | a akkermansia-muciniphila | |
| 653 | a risk | |
| 653 | a diet | |
| 653 | a mass | |
| 653 | a supplementation | |
| 653 | a ovariectomy | |
| 653 | a doxycycline | |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Lanham-New, S. A.4 aut |
| 700 | 1 | a Corfe, B. M.4 aut |
| 700 | 1 | a Gregson, C. L.4 aut |
| 700 | 1 | a Darling, A. L.4 aut |
| 700 | 1 | a Ahmadi, K. R.4 aut |
| 700 | 1 | a Gibson, P. S.4 aut |
| 700 | 1 | a Tobias, J. H.4 aut |
| 700 | 1 | a Ward, K. A.4 aut |
| 700 | 1 | a Traka, M. H.4 aut |
| 700 | 1 | a Rossi, M.4 aut |
| 700 | 1 | a Williams, C.4 aut |
| 700 | 1 | a Harvey, N. C.4 aut |
| 700 | 1 | a Cooper, C.4 aut |
| 700 | 1 | a Whelan, K.4 aut |
| 700 | 1 | a Uitterlinden, A. G.4 aut |
| 700 | 1 | a O'Toole, P. W.4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Compston, J. E.4 aut |
| 700 | 1 | a Ralston, S. H.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
| 773 | 0 | t Calcified Tissue Internationald : Springer Science and Business Media LLCg 110:3, s. 273-284q 110:3<273-284x 0171-967Xx 1432-0827 |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00223-021-00924-2.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/311618 |
| 856 | 4 8 | u https://doi.org/10.1007/s00223-021-00924-2 |
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