WFRF:(Pasanen M)
Sökning: WFRF:(Pasanen M) > Parity associates w...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02766naa a2200517 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147614607 | |
| 003 | SwePub | |
| 008 | 240811s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1476146072 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-021-25806-x2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kuisma, H4 aut |
| 245 | 1 0 | a Parity associates with chromosomal damage in uterine leiomyomas |
| 264 | c 2021-09-14 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Mechanical forces in a constrained cellular environment were recently established as a facilitator of chromosomal damage. Whether this could contribute to tumorigenesis is not known. Uterine leiomyomas are common neoplasms that display relatively few chromosomal aberrations. We hypothesized that if mechanical forces contribute to chromosomal damage, signs of this could be seen in uterine leiomyomas from parous women. We examined the karyotypes of 1946 tumors, and found a striking overrepresentation of chromosomal damage associated with parity. We then subjected myometrial cells to physiological forces similar to those encountered during pregnancy, and found this to cause DNA breaks and a DNA repair response. While mechanical forces acting in constrained cellular environments may thus contribute to neoplastic degeneration, and genesis of uterine leiomyoma, further studies are needed to prove possible causality of the observed association. No evidence for progression to malignancy was found. | |
| 700 | 1 | a Bramante, S4 aut |
| 700 | 1 | a Rajamaki, K4 aut |
| 700 | 1 | a Sipila, LJ4 aut |
| 700 | 1 | a Kaasinen, E4 aut |
| 700 | 1 | a Kaukomaa, J4 aut |
| 700 | 1 | a Palin, K4 aut |
| 700 | 1 | a Makinen, N4 aut |
| 700 | 1 | a Sjoberg, J4 aut |
| 700 | 1 | a Sarvilinna, N4 aut |
| 700 | 1 | a Taipale, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Kauppi, L4 aut |
| 700 | 1 | a Tumiati, M4 aut |
| 700 | 1 | a Hassinen, A4 aut |
| 700 | 1 | a Pitkaniemi, J4 aut |
| 700 | 1 | a Jalkanen, J4 aut |
| 700 | 1 | a Heikkinen, S4 aut |
| 700 | 1 | a Pasanen, A4 aut |
| 700 | 1 | a Heikinheimo, O4 aut |
| 700 | 1 | a Butzow, R4 aut |
| 700 | 1 | a Valimaki, N4 aut |
| 700 | 1 | a Aaltonen, LA4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 12:1, s. 5448-q 12:1<5448-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-021-25806-x.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147614607 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-021-25806-x |
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- Kuisma, H
- Bramante, S
- Rajamaki, K
- Sipila, LJ
- Kaasinen, E
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- Palin, K
- Makinen, N
- Sjoberg, J
- Sarvilinna, N
- Taipale, J
- Kauppi, L
- Tumiati, M
- Hassinen, A
- Pitkaniemi, J
- Jalkanen, J
- Heikkinen, S
- Pasanen, A
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