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Sökning: WFRF:(Rhee E. J.) > Circulating testica...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006011naa a2200709 4500
001oai:lup.lub.lu.se:93f3ae6f-1176-43dd-9e46-3373b4250428
003SwePub
008201109s2020 | |||||||||||000 ||eng|
009oai:gup.ub.gu.se/299784
0247 a https://lup.lub.lu.se/record/93f3ae6f-1176-43dd-9e46-3373b42504282 URI
0247 a https://doi.org/10.1073/pnas.20096061172 DOI
0247 a https://gup.ub.gu.se/publication/2997842 URI
040 a (SwePub)lud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ngo, Debbyu Beth Israel Deaconess Medical Center4 aut
2451 0a Circulating testican-2 is a podocyte-derived marker of kidney health
264 c 2020-09-21
264 1b Proceedings of the National Academy of Sciences,c 2020
300 a 10 s.
520 a In addition to their fundamental role in clearance, the kidneys release select molecules into the circulation, but whether any of these anabolic functions provides insight on kidney health is unknown. Using aptamer-based proteomics, we characterized arterial (A)-to-renal venous (V) gradients for >1,300 proteins in 22 individuals who underwent invasive sampling. Although most of the proteins that changed significantly decreased from A to V, consistent with renal clearance, several were found to increase, the most significant of which was testican-2. To assess the clinical implications of these physiologic findings, we examined proteomic data in the Jackson Heart Study (JHS), an African-American cohort (n = 1,928), with replication in the Framingham Heart Study (FHS), a White cohort (n = 1,621). In both populations, testican-2 had a strong, positive correlation with estimated glomerular filtration rate (eGFR). In addition, higher baseline testican-2 levels were associated with a lower rate of eGFR decline in models adjusted for age, gender, hypertension, type 2 diabetes, body mass index, baseline eGFR, and albuminuria. Glomerular expression of testican-2 in human kidneys was demonstrated by immunohistochemistry, immunofluorescence, and electron microscopy, while single-cell RNA sequencing of human kidneys showed expression of the cognate gene, SPOCK2, exclusively in podocytes. In vitro, testican-2 increased glomerular endothelial tube formation and motility, raising the possibility that its secretion has a functional role within the glomerulus. Taken together, our findings identify testican-2 as a podocyte-derived biomarker of kidney health and prognosis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a chronic kidney disease
653 a proteomics
653 a testican-2
7001 a Wen, Donghaiu Massachusetts General Hospital4 aut
7001 a Gao, Yanu University of Mississippi4 aut
7001 a Keyes, Michelle J.u Beth Israel Deaconess Medical Center4 aut
7001 a Drury, Erika R.u University of Rochester4 aut
7001 a Katz, Dan H.u Beth Israel Deaconess Medical Center4 aut
7001 a Benson, Mark D.u Beth Israel Deaconess Medical Center4 aut
7001 a Sinha, Sumitau Beth Israel Deaconess Medical Center4 aut
7001 a Shen, Dongxiaou Beth Israel Deaconess Medical Center4 aut
7001 a Farrell, Laurie A.u Beth Israel Deaconess Medical Center4 aut
7001 a Peterson, Bennet D.u Beth Israel Deaconess Medical Center4 aut
7001 a Friedman, David J.u Beth Israel Deaconess Medical Center4 aut
7001 a Elmariah, Sammyu Massachusetts General Hospital4 aut
7001 a Young, Bessie A.u University of Washington, Seattle,VA Puget Sound Health Care System4 aut
7001 a Smith, J. Gustavu Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Sahlgrenska University Hospital,Wallenberglaboratoriet,Institutionen för medicin,Wallenberg Laboratory,Institute of Medicine4 aut0 (Swepub:gu)xsmigu
7001 a Yang, Qiongu Boston University4 aut
7001 a Vasan, Ramachandran S.u National Heart Lung and Blood Institute,Boston University4 aut
7001 a Larson, Martin G.u Boston University,National Heart Lung and Blood Institute4 aut
7001 a Correa, Adolfou University of Mississippi4 aut
7001 a Humphreys, Benjamin D.u Washington University in St. Louis4 aut
7001 a Wang, Thomas J.u University of Texas Southwestern Medical Center4 aut
7001 a Pollak, Martin R.u Beth Israel Deaconess Medical Center4 aut
7001 a Wilson, James G.u Beth Israel Deaconess Medical Center4 aut
7001 a Gerszten, Robert E.u Beth Israel Deaconess Medical Center4 aut
7001 a Rhee, Eugene P.u Massachusetts General Hospital4 aut
7102 a Beth Israel Deaconess Medical Centerb Massachusetts General Hospital4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 117:40, s. 25026-25035q 117:40<25026-25035x 1091-6490x 0027-8424
7730 t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 117:40, s. 25026-25035q 117:40<25026-25035x 0027-8424
8564 u http://dx.doi.org/10.1073/pnas.2009606117y FULLTEXT
8564 u https://www.pnas.org/content/pnas/117/40/25026.full.pdf
8564 8u https://lup.lub.lu.se/record/93f3ae6f-1176-43dd-9e46-3373b4250428
8564 8u https://doi.org/10.1073/pnas.2009606117
8564 8u https://gup.ub.gu.se/publication/299784

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