WFRF:(Sorbe Bengt 1947 )
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Survival and prognostic factors in early-stage epithelial ovarian carcinoma treated with taxane-based adjuvant chemotherapy
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- Skírnisdóttir, Ingirídur (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Sorbe, Bengt, 1947- (författare)
- Örebro universitet,Hälsoakademin
- (creator_code:org_t)
- 2007-10-01
- 2007
- Engelska.
- Ingår i: International Journal of Gynecological Cancer. - Cambridge, Mass. : Blackwell. - 1048-891X .- 1525-1438. ; 17:6, s. 1231-1237
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- The present study was undertaken with the question about the outcome (recurrence-free survival, [RFS]) after adjuvant chemotherapy with taxane and carboplatin in the early stages of epithelial ovarian cancer after primary surgery. Treatment-related toxicity was also evaluated. A total of 113 patients were included in this study. The 5-year RFS rate for all 113 patients treated with adjuvant chemotherapy including taxane and carboplatin after primary surgery was 79%. The 5-year RFS rate for 85 patients in FIGO stage I was 85% and for 18 patients in FIGO stage II, it was 44%. For clear-cell carcinomas, the RFS was 87%. In univariate analysis, recurrent disease was associated with both FIGO stage and tumor grade, but in multivariate logistic regression analysis of prognostic factors for tumor recurrences, only FIGO stage (stage I versus stage II) was a significant and independent prognostic factor. However, an odds ratio (OR) of 1.9 for tumor grade (grade 3 versus grades 1–2) demonstrated two times increased risk for recurrence in a patient with a grade 3 tumor compared with grade 1–2 tumors. Furthermore, an OR of 0.39 for lymph node sampling versus no sampling meant 61% reduced risk for recurrence for a patient who had undergone lymph node sampling at surgical staging laparotomy. The major toxicities in the present study were myelosuppression (46%) and neurotoxicity (34%). Despite the use of prophylaxis, severe paclitaxel-related hypersensitivity occurred in three patients (3%).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Survival
- prognostic factors
- epithelial ovarian carcinoma
- chemotherapy
- MEDICINE
- MEDICIN
- Oncology
- Onkologi
- Cancer Epidemiology
- cancerepidemiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- International Journal of Gynecological Cancer (Sök värdpublikationen i LIBRIS)
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