Functional characterization of mosquito short neuropeptide F receptors

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Fältnamn	Indikatorer	Metadata
000		03132naa a2200313 4500
001		oai:slubar.slu.se:94385
003		SwePub
008		240410s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://res.slu.se/id/publ/943852 URI
024	7	a https://doi.org/10.1016/j.peptides.2018.03.0092 DOI
040		a (SwePub)slu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Christ, Peteru Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Växtskyddsbiologi,Department of Plant Protection Biology4 aut0 (Swepub:slu)96358
245	1 0	a Functional characterization of mosquito short neuropeptide F receptors
264	1	b Elsevier BV,c 2018
264	1	b Elsevier,c 2024
520		a Mosquito blood feeding transiently inhibits sugar-and host seeking through neuropeptide signaling. Short neuropeptide F (sNPF) is one of the neuromodulators involved in this regulation. Here, we identified the genes for the sNPF precursor and the sNPF receptor in the southern house mosquito, Culex quinquefasciatus. Comparative analyses are made with the genes of the sNPF precursor and receptor from two other important vectors, Aedes aegypti and Anopheles coluzzii. We functionally characterized the receptors in all three species using endogenous neuropeptides, and quantified their transcript expression following a blood meal and a sugar meal. Our analysis reveals several Cx. quinquefasciatus-specific duplications of the sNPF-3 isoform on the sNPF precursor, which are not reflected in the precursors of the other two species. In contrast, the structure of the sNPF receptors is highly conserved within mosquitoes, and a putative ligand binding region is proposed and discussed. Reflecting the high structural conservation, the sNPF receptor sensitivity to endogenous sNPF iso-forms is conserved across mosquito species. Using quantitative real time PCR, we demonstrate that transcript abundance of the sNPF receptor and precursor is regulated following feeding, only in Cx. quinquefasciatus. We discuss our findings in relation to previous work on sNPF signaling and its role in feeding regulation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
700	1	a Hill, Sharonu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Växtskyddsbiologi,Department of Plant Protection Biology4 aut0 (Swepub:slu)51024
700	1	a Ignell, Rickardu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Växtskyddsbiologi,Department of Plant Protection Biology4 aut0 (Swepub:slu)47630
710	2	a Sveriges lantbruksuniversitetb Växtskyddsbiologi4 org
710	2	a Sveriges lantbruksuniversitet
773	0	t Peptidesd : Elsevier BVg 103, s. 31-39q 103<31-39x 0196-9781x 1873-5169
856	4 8	u https://res.slu.se/id/publ/94385
856	4 8	u https://doi.org/10.1016/j.peptides.2018.03.009

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Av författaren/redakt...: Christ, Peter; Hill, Sharon; Ignell, Rickard

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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