WFRF:(Barrett D)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09264naa a2201609 4500 | |
| 001 | oai:gup.ub.gu.se/228197 | |
| 003 | SwePub | |
| 008 | 240910s2015 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:32ce0e9a-ae1e-4460-8497-2225a43c689d | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2281972 URI |
| 024 | 7 | a https://doi.org/10.1001/jama.2015.70082 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/77501932 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Di Angelantonio, E.4 aut |
| 245 | 1 0 | a Association of Cardiometabolic Multimorbidity With Mortality |
| 264 | 1 | b American Medical Association (AMA),c 2015 |
| 520 | a IMPORTANCE: The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS: Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128,843 deaths). The HRs from the Emerging Risk Factors Collaboration were compared with those from the UK Biobank (499,808 participants; years of baseline surveys: 2006-2010; latest mortality follow-up: November 2013; 7995 deaths). Cumulative survival was estimated by applying calculated age-specific HRs for mortality to contemporary US age-specific death rates. EXPOSURES: A history of 2 or more of the following: diabetes mellitus, stroke, myocardial infarction (MI). MAIN OUTCOMES AND MEASURES: All-cause mortality and estimated reductions in life expectancy. RESULTS: In participants in the Emerging Risk Factors Collaboration without a history of diabetes, stroke, or MI at baseline (reference group), the all-cause mortality rate adjusted to the age of 60 years was 6.8 per 1000 person-years. Mortality rates per 1000 person-years were 15.6 in participants with a history of diabetes, 16.1 in those with stroke, 16.8 in those with MI, 32.0 in those with both diabetes and MI, 32.5 in those with both diabetes and stroke, 32.8 in those with both stroke and MI, and 59.5 in those with diabetes, stroke, and MI. Compared with the reference group, the HRs for all-cause mortality were 1.9 (95% CI, 1.8-2.0) in participants with a history of diabetes, 2.1 (95% CI, 2.0-2.2) in those with stroke, 2.0 (95% CI, 1.9-2.2) in those with MI, 3.7 (95% CI, 3.3-4.1) in those with both diabetes and MI, 3.8 (95% CI, 3.5-4.2) in those with both diabetes and stroke, 3.5 (95% CI, 3.1-4.0) in those with both stroke and MI, and 6.9 (95% CI, 5.7-8.3) in those with diabetes, stroke, and MI. The HRs from the Emerging Risk Factors Collaboration were similar to those from the more recently recruited UK Biobank. The HRs were little changed after further adjustment for markers of established intermediate pathways (eg, levels of lipids and blood pressure) and lifestyle factors (eg, smoking, diet). At the age of 60 years, a history of any 2 of these conditions was associated with 12 years of reduced life expectancy and a history of all 3 of these conditions was associated with 15 years of reduced life expectancy. CONCLUSIONS AND RELEVANCE: Mortality associated with a history of diabetes, stroke, or MI was similar for each condition. Because any combination of these conditions was associated with multiplicative mortality risk, life expectancy was substantially lower in people with multimorbidity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Comorbidity | |
| 653 | a *Diabetes Mellitus/epidemiology | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a *Life Expectancy | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a *Mortality | |
| 653 | a *Myocardial Infarction/epidemiology | |
| 653 | a Risk Factors | |
| 653 | a *Stroke/epidemiology | |
| 653 | a Diabetes Mellitus: epidemiology | |
| 653 | a Myocardial Infarction: epidemiology | |
| 653 | a Stroke: epidemiology | |
| 700 | 1 | a Kaptoge, S.4 aut |
| 700 | 1 | a Wormser, D.4 aut |
| 700 | 1 | a Willeit, P.4 aut |
| 700 | 1 | a Butterworth, A. S.4 aut |
| 700 | 1 | a Bansal, N.4 aut |
| 700 | 1 | a O'Keeffe, L. M.4 aut |
| 700 | 1 | a Gao, P.4 aut |
| 700 | 1 | a Wood, A. M.4 aut |
| 700 | 1 | a Burgess, S.4 aut |
| 700 | 1 | a Freitag, D. F.4 aut |
| 700 | 1 | a Pennells, L.4 aut |
| 700 | 1 | a Peters, S. A.4 aut |
| 700 | 1 | a Hart, C. L.4 aut |
| 700 | 1 | a Haheim, L. L.4 aut |
| 700 | 1 | a Gillum, R. F.4 aut |
| 700 | 1 | a Nordestgaard, B. G.4 aut |
| 700 | 1 | a Psaty, B. M.4 aut |
| 700 | 1 | a Yeap, B. B.4 aut |
| 700 | 1 | a Knuiman, M. W.4 aut |
| 700 | 1 | a Nietert, P. J.4 aut |
| 700 | 1 | a Kauhanen, J.4 aut |
| 700 | 1 | a Salonen, J. T.4 aut |
| 700 | 1 | a Kuller, L. H.4 aut |
| 700 | 1 | a Simons, L. A.4 aut |
| 700 | 1 | a van der Schouw, Y. T.4 aut |
| 700 | 1 | a Barrett-Connor, E.4 aut |
| 700 | 1 | a Selmer, R.4 aut |
| 700 | 1 | a Crespo, C. J.4 aut |
| 700 | 1 | a Rodriguez, B.4 aut |
| 700 | 1 | a Verschuren, W. M.4 aut |
| 700 | 1 | a Salomaa, V.4 aut |
| 700 | 1 | a Svardsudd, K.4 aut |
| 700 | 1 | a van der Harst, P.4 aut |
| 700 | 1 | a Björkelund, Cecilia,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xbjoce |
| 700 | 1 | a Wilhelmsen, Lars,d 1932u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xwilhl |
| 700 | 1 | a Wallace, R. B.4 aut |
| 700 | 1 | a Brenner, H.4 aut |
| 700 | 1 | a Amouyel, P.4 aut |
| 700 | 1 | a Barr, E. L.4 aut |
| 700 | 1 | a Iso, H.4 aut |
| 700 | 1 | a Onat, A.4 aut |
| 700 | 1 | a Trevisan, M.4 aut |
| 700 | 1 | a D'Agostino, R. B., Sr.4 aut |
| 700 | 1 | a Cooper, C.4 aut |
| 700 | 1 | a Kavousi, M.4 aut |
| 700 | 1 | a Welin, Lennart4 aut |
| 700 | 1 | a Roussel, R.4 aut |
| 700 | 1 | a Hu, F. B.4 aut |
| 700 | 1 | a Sato, S.4 aut |
| 700 | 1 | a Davidson, K. W.4 aut |
| 700 | 1 | a Howard, B. V.4 aut |
| 700 | 1 | a Leening, M. J.4 aut |
| 700 | 1 | a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan |
| 700 | 1 | a Dorr, M.4 aut |
| 700 | 1 | a Deeg, D. J.4 aut |
| 700 | 1 | a Kiechl, S.4 aut |
| 700 | 1 | a Stehouwer, C. D.4 aut |
| 700 | 1 | a Nissinen, A.4 aut |
| 700 | 1 | a Giampaoli, S.4 aut |
| 700 | 1 | a Donfrancesco, C.4 aut |
| 700 | 1 | a Kromhout, D.4 aut |
| 700 | 1 | a Price, J. F.4 aut |
| 700 | 1 | a Peters, A.4 aut |
| 700 | 1 | a Meade, T. W.4 aut |
| 700 | 1 | a Casiglia, E.4 aut |
| 700 | 1 | a Lawlor, D. A.4 aut |
| 700 | 1 | a Gallacher, J.4 aut |
| 700 | 1 | a Nagel, D.4 aut |
| 700 | 1 | a Franco, O. H.4 aut |
| 700 | 1 | a Assmann, G.4 aut |
| 700 | 1 | a Dagenais, G. R.4 aut |
| 700 | 1 | a Jukema, J. W.4 aut |
| 700 | 1 | a Sundstrom, J.4 aut |
| 700 | 1 | a Woodward, M.4 aut |
| 700 | 1 | a Brunner, E. J.4 aut |
| 700 | 1 | a Khaw, K. T.4 aut |
| 700 | 1 | a Wareham, N. J.4 aut |
| 700 | 1 | a Whitsel, E. A.4 aut |
| 700 | 1 | a Njolstad, I.4 aut |
| 700 | 1 | a Hedblad, Bou Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-bhe |
| 700 | 1 | a Wassertheil-Smoller, S.4 aut |
| 700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
| 700 | 1 | a Rosamond, W. D.4 aut |
| 700 | 1 | a Selvin, E.4 aut |
| 700 | 1 | a Sattar, N.4 aut |
| 700 | 1 | a Thompson, S. G.4 aut |
| 700 | 1 | a Danesh, J.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
| 773 | 0 | t JAMAd : American Medical Association (AMA)g 314:1, s. 52-60q 314:1<52-60x 0098-7484x 1538-3598 |
| 856 | 4 | u https://jamanetwork.com/journals/jama/articlepdf/2382980/joi150068.pdf |
| 856 | 4 | u https://portal.research.lu.se/files/1961595/8866333.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26151266?dopt=Abstractx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1001/jama.2015.7008y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/228197 |
| 856 | 4 8 | u https://doi.org/10.1001/jama.2015.7008 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/7750193 |
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