Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

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Fältnamn	Indikatorer	Metadata
000		08123naa a2201777 4500
001		oai:DiVA.org:umu-128460
003		SwePub
008		161205s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1284602 URI
024	7	a https://doi.org/10.18632/oncotarget.110412 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Zhang, Mingfeng4 aut
245	1 0	a Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21
264		c 2016-08-01
264	1	b Impact Journals, LLC,c 2016
338		a electronic2 rdacarrier
520		a Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10(-15)), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10(-9)) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10(-8)). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 (NR5A2), chr8q24.21 (MYC) and chr5p15.33 (CLPTM1L-TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal (n = 10) and tumor (n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10(-8)). This finding was validated in a second set of paired (n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10(-4)-2.0x10(-3)). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Wang, Zhaoming4 aut
700	1	a Obazee, Ofure4 aut
700	1	a Jia, Jinping4 aut
700	1	a Childs, Erica J.4 aut
700	1	a Hoskins, Jason4 aut
700	1	a Figlioli, Gisella4 aut
700	1	a Mocci, Evelina4 aut
700	1	a Collins, Irene4 aut
700	1	a Chung, Charles C.4 aut
700	1	a Hautman, Christopher4 aut
700	1	a Arslan, Alan A.4 aut
700	1	a Beane-Freeman, Laura4 aut
700	1	a Bracci, Paige M.4 aut
700	1	a Buring, Julie4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Gallinger, Steven4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Goodman, Gary E.4 aut
700	1	a Goodman, Phyllis J.4 aut
700	1	a Kamineni, Aruna4 aut
700	1	a Kolonel, Laurence N.4 aut
700	1	a Kulke, Matthew H.4 aut
700	1	a Malats, Nuria4 aut
700	1	a Olson, Sara H.4 aut
700	1	a Sesso, Howard D.4 aut
700	1	a Visvanathan, Kala4 aut
700	1	a White, Emily4 aut
700	1	a Zheng, Wei4 aut
700	1	a Abnet, Christian C.4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Andreotti, Gabriella4 aut
700	1	a Brais, Lauren4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Basso, Daniela4 aut
700	1	a Berndt, Sonja I.4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Bijlsma, Maarten F.4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Burdette, Laurie4 aut
700	1	a Campa, Daniele4 aut
700	1	a Caporaso, Neil E.4 aut
700	1	a Capurso, Gabriele4 aut
700	1	a Cavestro, Giulia Martina4 aut
700	1	a Cotterchio, Michelle4 aut
700	1	a Costello, Eithne4 aut
700	1	a Elena, Joanne4 aut
700	1	a Boggi, Ugo4 aut
700	1	a Gaziano, J. Michael4 aut
700	1	a Gazouli, Maria4 aut
700	1	a Giovannucci, Edward L.4 aut
700	1	a Goggins, Michael4 aut
700	1	a Gross, Myron4 aut
700	1	a Haiman, Christopher A.4 aut
700	1	a Hassan, Manal4 aut
700	1	a Helzlsouer, Kathy J.4 aut
700	1	a Hu, Nan4 aut
700	1	a Hunter, David J.4 aut
700	1	a Iskierka-Jazdzewska, Elzbieta4 aut
700	1	a Jenab, Mazda4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Key, Timothy J.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Klein, Eric A.4 aut
700	1	a Kogevinas, Manolis4 aut
700	1	a Krogh, Vittorio4 aut
700	1	a Kupcinskas, Juozas4 aut
700	1	a Kurtz, Robert C.4 aut
700	1	a Landi, Maria T.4 aut
700	1	a Landi, Stefano4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Mambrini, Andrea4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Milne, Roger L.4 aut
700	1	a Neale, Rachel E.4 aut
700	1	a Oberg, Ann L.4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Patel, Alpa V.4 aut
700	1	a Peeters, Petra H. M.4 aut
700	1	a Peters, Ulrike4 aut
700	1	a Pezzilli, Raffaele4 aut
700	1	a Porta, Miquel4 aut
700	1	a Purdue, Mark4 aut
700	1	a Ramon Quiros, J.4 aut
700	1	a Riboli, Elio4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Scarpa, Aldo4 aut
700	1	a Scelo, Ghislaine4 aut
700	1	a Shu, Xiao-Ou4 aut
700	1	a Silverman, Debra T.4 aut
700	1	a Soucek, Pavel4 aut
700	1	a Strobel, Oliver4 aut
700	1	a Sund, Malinu Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap4 aut0 (Swepub:umu)masu0021
700	1	a Malecka-Panas, Ewa4 aut
700	1	a Taylor, Philip R.4 aut
700	1	a Tavano, Francesca4 aut
700	1	a Travis, Ruth C.4 aut
700	1	a Thornquist, Mark4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Tobias, Geoffrey S.4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Vashist, Yogesh4 aut
700	1	a Vodicka, Pavel4 aut
700	1	a Wactawski-Wende, Jean4 aut
700	1	a Wentzensen, Nicolas4 aut
700	1	a Yu, Herbert4 aut
700	1	a Yu, Kai4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Kooperberg, Charles4 aut
700	1	a Risch, Harvey A.4 aut
700	1	a Jacobs, Eric J.4 aut
700	1	a Li, Donghui4 aut
700	1	a Fuchs, Charles4 aut
700	1	a Hoover, Robert4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Petersen, Gloria M.4 aut
700	1	a Stolzenberg-Solomon, Rachael S.4 aut
700	1	a Wolpin, Brian M.4 aut
700	1	a Kraft, Peter4 aut
700	1	a Klein, Alison P.4 aut
700	1	a Canzian, Federico4 aut
700	1	a Amundadottir, Laufey T.4 aut
710	2	a Umeå universitetb Institutionen för kirurgisk och perioperativ vetenskap4 org
773	0	t Oncotargetd : Impact Journals, LLCg 7:41, s. 66328-66343q 7:41<66328-66343x 1949-2553
856	4	u https://umu.diva-portal.org/smash/get/diva2:1061768/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11041&path%5B%5D=34956
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128460
856	4 8	u https://doi.org/10.18632/oncotarget.11041

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Av författaren/redakt...: Zhang, Mingfeng; Wang, Zhaoming; Obazee, Ofure; Jia, Jinping; Childs, Erica J.; Hoskins, Jason; visa fler...; Figlioli, Gisell ...; Mocci, Evelina; Collins, Irene; Chung, Charles C ...; Hautman, Christo ...; Arslan, Alan A.; Beane-Freeman, L ...; Bracci, Paige M.; Buring, Julie; Duell, Eric J.; Gallinger, Steve ...; Giles, Graham G.; Goodman, Gary E.; Goodman, Phyllis ...; Kamineni, Aruna; Kolonel, Laurenc ...; Kulke, Matthew H ...; Malats, Nuria; Olson, Sara H.; Sesso, Howard D.; Visvanathan, Kal ...; White, Emily; Zheng, Wei; Abnet, Christian ...; Albanes, Demetri ...; Andreotti, Gabri ...; Brais, Lauren; Bueno-de-Mesquit ...; Basso, Daniela; Berndt, Sonja I.; Boutron-Ruault, ...; Bijlsma, Maarten ...; Brenner, Hermann; Burdette, Laurie; Campa, Daniele; Caporaso, Neil E ...; Capurso, Gabriel ...; Cavestro, Giulia ...; Cotterchio, Mich ...; Costello, Eithne; Elena, Joanne; Boggi, Ugo; Gaziano, J. Mich ...; Gazouli, Maria; Giovannucci, Edw ...; Goggins, Michael; Gross, Myron; Haiman, Christop ...; Hassan, Manal; Helzlsouer, Kath ...; Hu, Nan; Hunter, David J.; Iskierka-Jazdzew ...; Jenab, Mazda; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay-Tee; Klein, Eric A.; Kogevinas, Manol ...; Krogh, Vittorio; Kupcinskas, Juoz ...; Kurtz, Robert C.; Landi, Maria T.; Landi, Stefano; Le Marchand, Loi ...; Mambrini, Andrea; Mannisto, Satu; Milne, Roger L.; Neale, Rachel E.; Oberg, Ann L.; Panico, Salvator ...; Patel, Alpa V.; Peeters, Petra H ...; Peters, Ulrike; Pezzilli, Raffae ...; Porta, Miquel; Purdue, Mark; Ramon Quiros, J.; Riboli, Elio; Rothman, Nathani ...; Scarpa, Aldo; Scelo, Ghislaine; Shu, Xiao-Ou; Silverman, Debra ...; Soucek, Pavel; Strobel, Oliver; Sund, Malin; Malecka-Panas, E ...; Taylor, Philip R ...; Tavano, Francesc ...; Travis, Ruth C.; Thornquist, Mark; Tjonneland, Anne; Tobias, Geoffrey ...; Trichopoulos, Di ...; Vashist, Yogesh; Vodicka, Pavel; Wactawski-Wende, ...; Wentzensen, Nico ...; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquo ...; Kooperberg, Char ...; Risch, Harvey A.; Jacobs, Eric J.; Li, Donghui; Fuchs, Charles; Hoover, Robert; Hartge, Patricia; Chanock, Stephen ...; Petersen, Gloria ...; Stolzenberg-Solo ...; Wolpin, Brian M.; Kraft, Peter; Klein, Alison P.; Canzian, Federic ...; Amundadottir, La ...; visa färre...

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