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Cerebrolysin restor...
Cerebrolysin restores balance between excitatory and inhibitory amino acids in brain following concussive head injury : Superior neuroprotective effects of TiO2 nanowired drug delivery
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- Sharma, Hari Shanker (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Muresanu, Dafin F. (författare)
- Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.
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- Sahib, Seaab (författare)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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- Tian, Z. Ryan (författare)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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- Vicente Lafuente, Jose (författare)
- Univ Basque Country, UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain.
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- Buzoianu, Anca D. (författare)
- Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania.
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- Castellani, Rudy J. (författare)
- Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.
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- Nozari, Ala (författare)
- Massachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA.
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- Li, Cong (författare)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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- Zhang, Zhiquiang (författare)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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- Wiklund, Lars (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sharma, Aruna (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Brain protection strategies and nanomedicine. - : Elsevier BV. - 9780323989275 ; , s. 211-267
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Concussive head injury (CHI) often associated with military personnel, soccer players and related sports personnel leads to serious clinical situation causing lifetime disabilities. About 3-4 k head injury per 100 k populations are recorded in the United States since 2000-2014. The annual incidence of concussion has now reached to 1.2% of population in recent years. Thus, CHI inflicts a huge financial burden on the society for rehabilitation. Thus, new efforts are needed to explore novel therapeutic strategies to treat CHI cases to enhance quality of life of the victims. CHI is well known to alter endogenous balance of excitatory and inhibitory amino acid neurotransmitters in the central nervous system (CNS) leading to brain pathology. Thus, a possibility exists that restoring the balance of amino acids in the CNS following CHI using therapeutic measures may benefit the victims in improving their quality of life. In this investigation, we used a multimodal drug Cerebrolysin (Ever NeuroPharma, Austria) that is a well-balanced composition of several neurotrophic factors and active peptide fragments in exploring its effects on CHI induced alterations in key excitatory (Glutamate, Aspartate) and inhibitory (GABA, Glycine) amino acids in the CNS in relation brain pathology in dose and time-dependent manner. CHI was produced in anesthetized rats by dropping a weight of 114.6 g over the right exposed parietal skull from a distance of 20 cm height (0.224 N impact) and blood-brain barrier (BBB), brain edema, neuronal injuries and behavioral dysfunctions were measured 8, 24, 48 and 72 h after injury. Cerebrolysin (CBL) was administered (2.5, 5 or 10 mL/kg, i.v.) after 4-72 h following injury. Our observations show that repeated CBL induced a dose-dependent neuroprotection in CHI (5-10 mL/kg) and also improved behavioral functions. Interestingly when CBL is delivered through TiO2 nanowires superior neuroprotective effects were observed in CHI even at a lower doses (2.5-5 mL/kg). These observations are the first to demonstrate that CBL is effectively capable to attenuate CHI induced brain pathology and behavioral disturbances in a dose dependent manner, not reported earlier.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Concussive head injury
- Cerebrolysin
- Head injury in military
- Blood-brain barrier
- Brain edema
- Neuronal injury
- Glutamate
- Aspartate
- Glycine
- GABA
- Neuroprotection
- Nanowired delivery
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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- Av författaren/redakt...
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Sharma, Hari Sha ...
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Muresanu, Dafin ...
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Sahib, Seaab
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Tian, Z. Ryan
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Vicente Lafuente ...
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Buzoianu, Anca D ...
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visa fler...
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Castellani, Rudy ...
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Nozari, Ala
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Li, Cong
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Zhang, Zhiquiang
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Wiklund, Lars
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Sharma, Aruna
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Brain protection ...
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Uppsala universitet