Sökning: WFRF:(Dalianis Tina) > P16(INK4a) correlat...
Fältnamn | Indikatorer | Metadata |
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000 | 02819naa a2200385 4500 | |
001 | oai:DiVA.org:umu-48181 | |
003 | SwePub | |
008 | 111010s2005 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1959483 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-481812 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19594832 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mellin Dahlstrand, Hannau Karolinska Institutet4 aut |
245 | 1 0 | a P16(INK4a) correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma. |
264 | 1 | c 2005 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Human papillomavirus (HPV) in tonsillar carcinoma is correlated with favourable clinical outcome. Here, p16(INK4A), in situ HPV DNA hybridisation (ISH) and HPVL1 capsid detection were evaluated in tonsillar carcinoma to predict the response to radiotherapy (RT) and prognosis. MATERIALS AND METHODS: Fifty-one pre-treatment paraffin-embedded tonsillar cancer biopsies were analysed. Immunohistochemistry (IHC) was used for p16(INK4A) and HPVL1 capsid analysis and PCR and ISH for HPV detection. RESULTS: High-risk HPV DNA was detected by PCR in 49% of the tumours. P16(INK4a) staining was correlated to HPV In the high-grade p16(INK4a) staining group, 94% had a complete RT response. High p16(INK4a) staining as well as the HPV PCR-positive cases had a favourable prognosis. HPV DNA ISH and L1 IHC could not predict RT response or clinical outcome. CONCLUSION: P16(INK4a) overexpression was correlated to HPV in tonsillar carcinoma and is useful for predicting RT response and prognosis in tonsillar carcinoma patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a onkologi | |
653 | a Oncology | |
700 | 1 | a Lindquist, Davidu Karolinska Instituet, Institutionen för Onkologi-Patologi4 aut0 (Swepub:umu)dali0066 |
700 | 1 | a Björnestål, Linda4 aut |
700 | 1 | a Ohlsson, Ann4 aut |
700 | 1 | a Dalianis, Tinau Karolinska Institutet4 aut |
700 | 1 | a Munck-Wikland, Evau Karolinska Institutet4 aut |
700 | 1 | a Elmberger, Göranu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Instituet, Institutionen för Onkologi-Patologi4 org |
773 | 0 | t Anticancer Researchg 25:6C, s. 4375-83q 25:6C<4375-83x 0250-7005x 1791-7530 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-48181 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1959483 |
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