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Sökning: WFRF:(Ferraz Natalia 1976 ) > In Vitro Biological...

In Vitro Biological Impact of Nanocellulose Fibers on Human Gut Bacteria and Gastrointestinal Cells

Lopes, Viviana R. (författare)
Uppsala universitet,Nanoteknologi och funktionella material
Strömme, Maria, 1970- (författare)
Uppsala universitet,Nanoteknologi och funktionella material
Ferraz, Natalia, 1976- (författare)
Uppsala universitet,Nanoteknologi och funktionella material
 (creator_code:org_t)
2020-06-12
2020
Engelska.
Ingår i: Nanomaterials. - : MDPI. - 2079-4991. ; 10:6
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Wood-derived nanofibrillated cellulose (NFC) has long been recognized as a valuable nanomaterial for food-related applications. However, the safety of NFC cannot be predicted just from the chemical nature of cellulose, and there is a need to establish the effect of the nanofibers on the gastrointestinal tract, to reassure the safe use of NFC in food-related products. The present work selected the intestinal cells Caco-2 and the gut bacteria Escherichia coli and Lactobacillus reuteri to evaluate the in vitro biological response to NFC. NFC materials with different surface modifications (carboxymethylation, hydroxypropyltrimethylammonium substitution, phosphorylation and sulfoethylation) and unmodified NFC were investigated. The materials were characterized in terms of surface functional group content, fiber morphology, zeta potential and degree of crystallinity. The Caco-2 cell response to the materials was evaluated by assessing metabolic activity and cell membrane integrity. The effects of the NFC materials on the model bacteria were evaluated by measuring bacterial growth (optical density at 600 nm) and by determining colony forming units counts after NFC exposure. Results showed no sign of cytotoxicity in Caco-2 cells exposed to the NFC materials, and NFC surface functionalization did not impact the cell response. Interestingly, a bacteriostatic effect on E. coli was observed while the materials did not affect the growth of L. reuteri. The present findings are foreseen to contribute to increase the knowledge about the potential oral toxicity of NFC and, in turn, add to the development of safe NFC-based food products.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Nanoteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Nano-technology (hsv//eng)

Nyckelord

nanofibrillated cellulose
oral toxicity
nanotoxicity
surface chemistry
normal intestinal flora
Engineering Science with specialization in Nanotechnology and Functional Materials
Teknisk fysik med inriktning mot nanoteknologi och funktionella material

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Av författaren/redakt...
Lopes, Viviana R ...
Strömme, Maria, ...
Ferraz, Natalia, ...
Om ämnet
TEKNIK OCH TEKNOLOGIER
TEKNIK OCH TEKNO ...
och Nanoteknik
Artiklar i publikationen
Nanomaterials
Av lärosätet
Uppsala universitet

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