Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

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Fältnamn	Indikatorer	Metadata
000		13117naa a2201201 4500
001		oai:DiVA.org:uu-275556
003		SwePub
008		160204s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2755562 URI
024	7	a https://doi.org/10.1007/s00401-015-1509-x2 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kovacs, Gabor G.4 aut
245	1 0	a Aging-related tau astrogliopathy (ARTAG) :b harmonized evaluation strategy
264		c 2015-12-10
264	1	b Springer Science and Business Media LLC,c 2016
338		a print2 rdacarrier
520		a Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a Aging
653		a ARTAG
653		a Tau astrogliopathy
653		a Tau
700	1	a Ferrer, Isidrou Univ Barcelona, Bellvitge Univ Hosp, Hosp Llobregat, Inst Neuropathol, Barcelona, Spain.;Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA.4 aut
700	1	a Grinberg, Lea T.u Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.4 aut
700	1	a Alafuzoff, Irinau Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)irial548
700	1	a Attems, Johannesu Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.4 aut
700	1	a Budka, Herbertu Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland.4 aut
700	1	a Cairns, Nigel J.u Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA.4 aut
700	1	a Crary, John F.u Icahn Sch Med Mt Sinai, Friedman Brain Inst, Dept Pathol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA.4 aut
700	1	a Duyckaerts, Charlesu Univ Paris 04, UPMC, Hop La Salpetriere, AP HP,Neuropathol Dept, Paris, France.4 aut
700	1	a Ghetti, Bernardinou Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46204 USA.4 aut
700	1	a Halliday, Glenda M.u GMH Neurosci Res Australia, Sydney, NSW, Australia.;Univ New S Wales, Sydney, NSW, Australia.4 aut
700	1	a Ironside, James W.u Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.4 aut
700	1	a Love, Sethu Univ Bristol, Southmead Hosp, Inst Clin Neurosci, Bristol, Avon, England.4 aut
700	1	a Mackenzie, Ian R.u Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada.4 aut
700	1	a Munoz, David G.u St Michaels Hosp, Div Pathol, Toronto, ON M5B 1W8, Canada.4 aut
700	1	a Murray, Melissa E.u Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA.4 aut
700	1	a Nelson, Peter T.u Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA.;Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.4 aut
700	1	a Takahashi, Hitoshiu Niigata Univ, Dept Pathol, Brain Res Inst, Niigata 9518585, Japan.4 aut
700	1	a Trojanowski, John Q.u Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA.4 aut
700	1	a Ansorge, Olafu John Radcliffe Hosp, Dept Neuropathol, Oxford OX3 9DU, England.4 aut
700	1	a Arzberger, Thomasu Univ Munich, Dept Psychiat & Psychotherapy, Ctr Neuropathol & Prion Res, Munich, Germany.4 aut
700	1	a Baborie, Atiku Walton Ctr, Dept Neuropathol, Liverpool, Merseyside, England.4 aut
700	1	a Beach, Thomas G.u Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ 85351 USA.4 aut
700	1	a Bieniek, Kevin F.u Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA.4 aut
700	1	a Bigio, Eileen H.u Northwestern Univ, Feinberg Sch Med, Northwestern ADC Neuropathol Core, Chicago, IL 60611 USA.4 aut
700	1	a Bodi, Istvanu Kings Coll Hosp London, London Neurodegenerat Brain Bank, Clin Neuropathol, London, England.4 aut
700	1	a Dugger, Brittany N.u Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ 85351 USA.;Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.4 aut
700	1	a Feany, Melu Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA USA.4 aut
700	1	a Gelpi, Ellenu Biobank Hosp Clin IDIBAPS, Inst Invest Biomed August Pi & Sunyer, Neurol Tissue Bank, Barcelona, Spain.4 aut
700	1	a Gentleman, Stephen M.u Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.4 aut
700	1	a Giaccone, Giorgiou IRCCS Fdn Carlo Besta Neurol Inst, Milan, Italy.4 aut
700	1	a Hatanpaa, Kimmo J.u Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA.4 aut
700	1	a Heale, Richardu Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.4 aut
700	1	a Hof, Patrick R.u Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Friedman Brain Inst, Fishberg Dept Neurosci, New York, NY 10029 USA.4 aut
700	1	a Hofer, Monikau John Radcliffe Hosp, Dept Neuropathol, Oxford OX3 9DU, England.4 aut
700	1	a Hortobagyi, Tiboru Univ Debrecen, Fac Med, Inst Pathol, Dept Neuropathol, H-4032 Debrecen, Hungary.4 aut
700	1	a Jellinger, Kurtu Inst Clin Neurobiol, A-1150 Vienna, Austria.4 aut
700	1	a Jicha, Gregory A.u Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.;Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA.4 aut
700	1	a Ince, Paulu Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England.4 aut
700	1	a Kofler, Juliau Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA.4 aut
700	1	a Koevari, Enikoeu Univ Hosp, Dept Mental Hlth & Psychiat, Geneva, Switzerland.;Univ Geneva, Sch Med, Geneva, Switzerland.4 aut
700	1	a Kril, Jillian J.u Univ Sydney, Sydney Med Sch, Discipline Pathol, Sydney, NSW 2006, Australia.4 aut
700	1	a Mann, David M.u Univ Manchester, Fac Med & Hlth Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England.4 aut
700	1	a Matej, Radoslavu Thomayer Hosp, Dept Pathol & Mol Med, Prague 4, Czech Republic.4 aut
700	1	a McKee, Ann C.u Boston Univ, Sch Med & VA Healthcare Syst, Dept Neurol & Pathol, Boston, MA 02118 USA.4 aut
700	1	a McLean, Catrionau Alfred Hosp, Dept Anat Pathol, Prahran, Vic 3004, Australia.4 aut
700	1	a Milenkovic, Ivanu Med Univ Vienna, Neurol, A-1097 Vienna, Austria.;Med Univ Vienna, Dept Neurol, Vienna, Austria.4 aut
700	1	a Montine, Thomas J.u Univ Washington, Dept Pathol, Seattle, WA 98195 USA.4 aut
700	1	a Murayama, Shigeou Tokyo Metropolitan Geriatr Hosp, Dept Neuropathol, Brain Bank Aging Res, Tokyo 173, Japan.;Inst Gerontol, Tokyo, Japan.4 aut
700	1	a Lee, Edward B.u Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA.4 aut
700	1	a Rahimi, Jasminu Med Univ Vienna, Neurol, A-1097 Vienna, Austria.4 aut
700	1	a Rodriguez, Roberta D.u Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp LIM22, Physiopathol Aging Lab, Sao Paulo, Brazil.4 aut
700	1	a Rozemuller, Annemiekeu Vrije Univ Amsterdam, Med Ctr, Netherlands Brainbank, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands.4 aut
700	1	a Schneider, Julie A.u Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.4 aut
700	1	a Schultz, Christianu Heidelberg Univ, Ctr Biomed & Med Technol Mannheim, Inst Neuroanat, Heidelberg, Germany.;Heidelberg Univ, Med Fac Mannheim, Heidelberg, Germany.4 aut
700	1	a Seeley, Williamu Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA.4 aut
700	1	a Seilhean, Danielleu Univ Paris 04, UPMC, Hop La Salpetriere, AP HP,Neuropathol Dept, Paris, France.4 aut
700	1	a Smith, Colinu Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.4 aut
700	1	a Tagliavini, Fabriziou IRCCS Fdn Carlo Besta Neurol Inst, Milan, Italy.4 aut
700	1	a Takao, Masakiu Saitama Med Univ, Int Med Ctr, Dept Neurol, Saitama, Japan.4 aut
700	1	a Thal, Dietmar Rudolfu Univ Ulm, Inst Pathol, Neuropathol Lab, D-89081 Ulm, Germany.;Katholieke Univ Leuven, Dept Neurosci, B-3000 Louvain, Belgium.4 aut
700	1	a Toledo, Jon B.u Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA.4 aut
700	1	a Tolnay, Markusu Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland.4 aut
700	1	a Troncoso, Juan C.u Johns Hopkins Univ, Sch Med, Dept Pathol, Div Neuropathol, Baltimore, MD 21205 USA.4 aut
700	1	a Vinters, Harry V.u Univ Calif Los Angeles, Med Ctr, Brain Res Inst, Sect Neuropathol,Dept Pathol & Lab Med, Los Angeles, CA 90024 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Med Ctr, Brain Res Inst, Dept Neurol, Los Angeles, CA 90095 USA.4 aut
700	1	a Weis, Sergeu Johannes Kepler Univ Linz, Kepler Univ Hosp, Sch Med, Dept Pathol & Neuropathol,Lab Neuropathol, A-4040 Linz, Austria.4 aut
700	1	a Wharton, Stephen B.u Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England.4 aut
700	1	a White, Charles L., IIIu Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA.4 aut
700	1	a Wisniewski, Thomasu NYU, Sch Med, Dept Neurol, Ctr Cognit Neurol, New York, NY 10016 USA.;NYU, Sch Med, Dept Pathol, Ctr Cognit Neurol, New York, NY 10016 USA.;NYU, Sch Med, Dept Psychiat, Ctr Cognit Neurol, New York, NY 10016 USA.4 aut
700	1	a Woulfe, John M.u Univ Ottawa, Ottawa Hosp, Res Inst, Dept Pathol & Lab Med,Ctr Canc Therapeut, Ottawa, ON, Canada.4 aut
700	1	a Yamada, Masahitou Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa, Japan.4 aut
700	1	a Dickson, Dennis W.u Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA.4 aut
710	2	a Univ Barcelona, Bellvitge Univ Hosp, Hosp Llobregat, Inst Neuropathol, Barcelona, Spain.;Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA.b Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.4 org
773	0	t Acta Neuropathologicad : Springer Science and Business Media LLCg 131:1, s. 87-102q 131:1<87-102x 0001-6322x 1432-0533
856	4	u https://europepmc.org/articles/pmc4879001?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275556
856	4 8	u https://doi.org/10.1007/s00401-015-1509-x

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Av författaren/redakt...: Kovacs, Gabor G.; Ferrer, Isidro; Grinberg, Lea T.; Alafuzoff, Irina; Attems, Johannes; Budka, Herbert; visa fler...; Cairns, Nigel J.; Crary, John F.; Duyckaerts, Char ...; Ghetti, Bernardi ...; Halliday, Glenda ...; Ironside, James ...; Love, Seth; Mackenzie, Ian R ...; Munoz, David G.; Murray, Melissa ...; Nelson, Peter T.; Takahashi, Hitos ...; Trojanowski, Joh ...; Ansorge, Olaf; Arzberger, Thoma ...; Baborie, Atik; Beach, Thomas G.; Bieniek, Kevin F ...; Bigio, Eileen H.; Bodi, Istvan; Dugger, Brittany ...; Feany, Mel; Gelpi, Ellen; Gentleman, Steph ...; Giaccone, Giorgi ...; Hatanpaa, Kimmo ...; Heale, Richard; Hof, Patrick R.; Hofer, Monika; Hortobagyi, Tibo ...; Jellinger, Kurt; Jicha, Gregory A ...; Ince, Paul; Kofler, Julia; Koevari, Enikoe; Kril, Jillian J.; Mann, David M.; Matej, Radoslav; McKee, Ann C.; McLean, Catriona; Milenkovic, Ivan; Montine, Thomas ...; Murayama, Shigeo; Lee, Edward B.; Rahimi, Jasmin; Rodriguez, Rober ...; Rozemuller, Anne ...; Schneider, Julie ...; Schultz, Christi ...; Seeley, William; Seilhean, Daniel ...; Smith, Colin; Tagliavini, Fabr ...; Takao, Masaki; Thal, Dietmar Ru ...; Toledo, Jon B.; Tolnay, Markus; Troncoso, Juan C ...; Vinters, Harry V ...; Weis, Serge; Wharton, Stephen ...; White, Charles L ...; Wisniewski, Thom ...; Woulfe, John M.; Yamada, Masahito; Dickson, Dennis ...; visa färre...

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