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Associations of Ser...
Associations of Serum Testosterone and Sex Hormone-Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men.
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Yeap, Bu B (author)
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Marriott, Ross J (author)
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Antonio, Leen (author)
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Raj, Suchitra (author)
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Dwivedi, Girish (author)
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Reid, Christopher M (author)
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Anawalt, Bradley D (author)
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Bhasin, Shalender (author)
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Dobs, Adrian S (author)
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Handelsman, David J (author)
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Hankey, Graeme J (author)
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Haring, Robin (author)
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Matsumoto, Alvin M (author)
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Norman, Paul E (author)
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O'Neill, Terence W (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Orwoll, Eric S (author)
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Vanderschueren, Dirk (author)
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Wittert, Gary A (author)
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Wu, Frederick C W (author)
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Murray, Kevin (author)
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Annals of internal medicine. - 1539-3704. ; 175:2, s. 159-170
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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Abstract
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- The influence of testosterone on risk for cardiovascular events in men is uncertain. Previous observational studies of sex hormones and incident cardiovascular disease in men have reported inconsistent findings, limited by cohort sizes and different selection criteria.To analyze associations of serum total testosterone and sex hormone-binding globulin (SHBG) with incident cardiovascular events in men.Cohort study.UK Biobank prospective cohort.Community-dwelling men aged 40 to 69 years.Testosterone and SHBG were assayed, and free testosterone was calculated. Cox proportional hazards regression was done, with outcomes of incident myocardial infarction (MI), hemorrhagic stroke (HS), ischemic stroke (IS), heart failure (HF), and major adverse cardiovascular events (MACE), adjusted for sociodemographic, lifestyle, and medical factors.Of 210700 men followed for 9 years, 8790 (4.2%) had an incident cardiovascular event. After adjustment for key variables, lower total testosterone concentrations (quintile 1 vs. quintile 5) were not associated with incident MI (fully adjusted hazard ratio [HR], 0.89 [95% CI, 0.80 to 1.00]), HS (HR, 0.94 [CI, 0.70 to 1.26]), IS (HR, 0.95 [CI, 0.82 to 1.10]), HF (HR, 1.15 [CI, 0.91 to 1.45]), or MACE (HR, 0.92 [CI, 0.84 to 1.00]). Men with lower calculated free testosterone values had a lower incidence of MACE (HR, 0.90 [CI, 0.84 to 0.97]). Lower SHBG concentrations were associated with higher incidence of MI (HR, 1.23 [CI, 1.09 to 1.38]) and lower incidence of IS (HR, 0.79 [CI, 0.67 to 0.94]) and HF (HR, 0.69 [CI, 0.54 to 0.89]), but not with HS (HR, 0.81 [CI, 0.57 to 1.14]) or MACE (HR, 1.01 [CI, 0.92 to 1.11]).Observational study; single baseline measurement of testosterone and SHBG.Men with lower total testosterone concentrations were not at increased risk for MI, stroke, HF, or MACE. Calculated free testosterone may be associated with risk for MACE. Men with lower SHBG concentrations have higher risk for MI but lower risk for IS and HF, with causality to be determined.Western Australian Health Translation Network, Medical Research Future Fund, and Lawley Pharmaceuticals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
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Yeap, Bu B
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Marriott, Ross J
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Antonio, Leen
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Raj, Suchitra
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Dwivedi, Girish
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Reid, Christophe ...
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show more...
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Anawalt, Bradley ...
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Bhasin, Shalende ...
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Dobs, Adrian S
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Handelsman, Davi ...
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Hankey, Graeme J
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Haring, Robin
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Matsumoto, Alvin ...
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Norman, Paul E
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O'Neill, Terence ...
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Ohlsson, Claes, ...
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Orwoll, Eric S
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Vanderschueren, ...
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Wittert, Gary A
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Wu, Frederick C ...
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Murray, Kevin
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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University of Gothenburg