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  • Sabir, Emad F.Linköpings universitet,Urologi,Hälsouniversitetet (författare)

Impact of hospital volume on local recurrence and distant metastasis in bladder cancer patients treated with radical cystectomy in Sweden

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2013-04-16
  • Medical Journals Sweden AB,2013

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:b3f30e34-7279-4abb-b4b6-334cea56866d
  • https://lup.lub.lu.se/record/4258978URI
  • https://doi.org/10.3109/21681805.2013.787118DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199937URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85636URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103728URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objective. This study evaluated the impact of hospital volume on local recurrence and distant metastasis in a population-based series of radical cystectomy patients in Sweden. Material and methods. All patients who underwent cystectomy for bladder cancer in 1997-2002 in Sweden and were reported to the National Bladder Cancer Registry were included. A high-volume hospital (HVH) was defined as one with >= 10 cystectomies/year and a low-volume hospital (LVH) as one with <10 cystectomies/year. Information on preoperative tumour, node, metastasis (TNM) classification, operative procedure, postoperative course and follow-up was obtained from medical records. Results. Of the 1126 patients, 827 (74%) were males. The mean age was 66 years and median follow-up 47 months. Of the 610 (54%) HVH patients, 68 (11%) were pT0, 123 (20%) pT2 and 69 (11%) were microscopic non-radical. Corresponding figures for the 516 (46%) LVH patients were 35 (7%), 68 (13%), 191 (37%), 222 (43%) and 96 (19%). Local recurrence was observed in 245 patients (22%): 113 (19%) at HVHs and 132 (26%) at LVHs. Distant metastasis was found in 363 (32%): 203 (33%) at HVHs and 160 (31%) at LVHs. Perioperative chemotherapy was given to 193 (17%). Multivariate Cox proportional hazards analysis showed that local recurrence was associated with LVHs and non-organ-confined disease, whereas distant metastasis was correlated with non-organ-confined disease and lymph-node metastases. Conclusions. In this retrospective analysis, local tumour recurrence after cystectomy was common, particularly in patients with non-organ-confined disease. Furthermore, local recurrence was more frequent at LVHs than HVHs, and overall survival was better at HVHs. These findings suggest that concentrating cystectomies in HVHs may improve outcomes such as local recurrence and overall survival.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Holmang, StenSahlgrens University Hospital, Sweden (författare)
  • Liedberg, FredrikLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Urological research, Malmö,Lund University Research Groups,Urology,Lund University, Sweden(Swepub:lu)urok-fli (författare)
  • Ljungberg, BörjeUmeå universitet,Urologi och andrologi,Umeå University, Sweden(Swepub:umu)bolj0001 (författare)
  • Malmström, Per-UnoUppsala universitet,Urologkirurgi,University of Uppsala Hospital, Sweden(Swepub:uu)perunoms (författare)
  • Månsson, WikingLund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups,SUS, Sweden(Swepub:lu)uro-wma (författare)
  • Wijkstrom, HansKarolinska University Hospital, Sweden (författare)
  • Jahnson, StaffanÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Urologiska kliniken i Östergötland(Swepub:liu)staja74 (författare)
  • Linköpings universitetUrologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scandinavian Journal of Urology: Medical Journals Sweden AB47:6, s. 483-4902168-18132168-1805

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