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Sökning: WFRF:(Lim S. Sam) > Accrual of Atherosc...

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FältnamnIndikatorerMetadata
00006584naa a2200793 4500
001oai:lup.lub.lu.se:6e9f890b-67eb-45ac-975b-2b491c353f69
003SwePub
008200910s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6e9f890b-67eb-45ac-975b-2b491c353f692 URI
0247 a https://doi.org/10.1002/art.413922 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Urowitz, Murray B.u University of Toronto4 aut
2451 0a Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort
264 c 2020-08-25
264 1b Wiley,c 2020
300 a 7 s.
520 a Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between 1999 and 2017. AVEs were attributed to atherosclerosis based on SLE being inactive at the time of the AVE as well as typical atherosclerotic changes observed on imaging or pathology reports and/or evidence of atherosclerosis elsewhere. Analyses included descriptive statistics, rate of AVEs per 1,000 patient-years, and univariable and multivariable relative risk regression models. Results: Of the 1,848 patients enrolled in the cohort, 1,710 had ≥1 follow-up visit after enrollment, for a total of 13,666 patient-years. Of these 1,710 patients, 3.6% had ≥1 AVEs attributed to atherosclerosis, for an event rate of 4.6 per 1,000 patient-years. In multivariable analyses, lower AVE rates were associated with antimalarial treatment (hazard ratio [HR] 0.54 [95% confidence interval (95% CI) 0.32–0.91]), while higher AVE rates were associated with any prior vascular event (HR 4.00 [95% CI 1.55–10.30]) and a body mass index of >40 kg/m2 (HR 2.74 [95% CI 1.04–7.18]). A prior AVE increased the risk of subsequent AVEs (HR 5.42 [95% CI 3.17–9.27], P < 0.001). Conclusion: The prevalence of AVEs and the rate of AVE accrual demonstrated in the present study is much lower than that seen in previously published data. This may be related to better control of both the disease activity and classic risk factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Gladman, Dafna D.u University of Toronto4 aut
7001 a Farewell, Vernonu University of Cambridge4 aut
7001 a Su, Jiandongu University of Toronto4 aut
7001 a Romero-Diaz, Juanitau Salvador Zubirán National Institute of Health Sciences and Nutrition4 aut
7001 a Bae, Sang Cheolu Hanyang University4 aut
7001 a Fortin, Paul R.u Laval University4 aut
7001 a Sanchez-Guerrero, Jorgeu University of Toronto4 aut
7001 a Clarke, Ann Elaineu University of Calgary4 aut
7001 a Bernatsky, Sashau McGill University Health Center4 aut
7001 a Gordon, Carolineu University of Birmingham4 aut
7001 a Hanly, John G.u Dalhousie University4 aut
7001 a Wallace, Daniel J.u University of California, Los Angeles4 aut
7001 a Isenberg, David A.u Royal Free Hospital4 aut
7001 a Rahman, Anisuru Royal Free Hospital4 aut
7001 a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut
7001 a Ginzler, Ellenu SUNY Downstate Health Sciences University4 aut
7001 a Alarcón, Graciela S.u University of Alabama4 aut
7001 a Chatham, W. Winnu University of Alabama4 aut
7001 a Petri, Michelle A.u Johns Hopkins University School of Medicine4 aut
7001 a Bruce, Ian N.u University of Manchester4 aut
7001 a Khamashta, Munther A.u King's College London,St Thomas' Hospital4 aut
7001 a Aranow, Cynthiau Feinstein Institute for Medical Research4 aut
7001 a Dooley, Mary Anneu University of North Carolina4 aut
7001 a Manzi, Susanu Allegheny Health Network4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University4 aut
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)reum-oni
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)reum-ajo
7001 a Steinsson, Kristjánu National University Hospital of Iceland4 aut
7001 a Zoma, Asad A.u Hairmyres Hospital4 aut
7001 a Ruiz-Irastorza, Guillermou University of the Basque Country4 aut
7001 a Lim, S. Samu Emory University4 aut
7001 a Kalunian, Kenneth C.u University of California, San Diego4 aut
7001 a Ỉnanç, Muratu Istanbul University4 aut
7001 a van Vollenhoven, Ronaldu Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Ramos-Casals, Manuelu Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)4 aut
7001 a Kamen, Diane L.u Medical University of South Carolina4 aut
7001 a Jacobsen, Sorenu Copenhagen University Hospital4 aut
7001 a Peschken, Christine A.u University of Manitoba4 aut
7001 a Askanase, Ancau Indian Institute of Technology4 aut
7001 a Stoll, Thomasu Cantonal Hospital of Olten4 aut
7102 a University of Torontob University of Cambridge4 org
7730 t Arthritis and Rheumatologyd : Wileyg 72:10, s. 1734-1740q 72:10<1734-1740x 2326-5191x 2326-5205
8564 u http://dx.doi.org/10.1002/art.41392y FULLTEXT
8564 u http://pure-oai.bham.ac.uk/ws/files/111107826/UrowitzMB2020Accrual.pdf
8564 8u https://lup.lub.lu.se/record/6e9f890b-67eb-45ac-975b-2b491c353f69
8564 8u https://doi.org/10.1002/art.41392

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