Sökning: WFRF:(Lori F) > Genetic variation i...
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000 | 09986naa a2202269 4500 | |
001 | oai:DiVA.org:uu-131527 | |
003 | SwePub | |
008 | 101004s2010 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:7c7e3cf9-9e3d-4371-9139-74000ff2b213 | |
009 | oai:prod.swepub.kib.ki.se:120004916 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1315272 URI |
024 | 7 | a https://doi.org/10.1038/ng.5212 DOI |
024 | 7 | a https://lup.lub.lu.se/record/15698742 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1200049162 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Saxena, Richa4 aut |
245 | 1 0 | a Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge |
264 | c 2010-01-17 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
520 | a Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18). | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Pankow, James S4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Bouatia-Naji, Nabila4 aut |
700 | 1 | a Dupuis, Josée4 aut |
700 | 1 | a Jackson, Anne U4 aut |
700 | 1 | a Kao, W H Linda4 aut |
700 | 1 | a Li, Man4 aut |
700 | 1 | a Glazer, Nicole L4 aut |
700 | 1 | a Manning, Alisa K4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Stringham, Heather M4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Boesgaard, Trine W4 aut |
700 | 1 | a Lecoeur, Cécile4 aut |
700 | 1 | a Shrader, Peter4 aut |
700 | 1 | a O'Connell, Jeffrey4 aut |
700 | 1 | a Ingelsson, Eriku Karolinska Institutet,Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Couper, David J4 aut |
700 | 1 | a Rice, Kenneth4 aut |
700 | 1 | a Song, Kijoung4 aut |
700 | 1 | a Andreasen, Camilla H4 aut |
700 | 1 | a Dina, Christian4 aut |
700 | 1 | a Köttgen, Anna4 aut |
700 | 1 | a Le Bacquer, Olivier4 aut |
700 | 1 | a Pattou, François4 aut |
700 | 1 | a Taneera, Jalalu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)stem-jta |
700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
700 | 1 | a Rybin, Denis4 aut |
700 | 1 | a Ardlie, Kristin4 aut |
700 | 1 | a Sampson, Michael4 aut |
700 | 1 | a Qi, Lu4 aut |
700 | 1 | a van Hoek, Mandy4 aut |
700 | 1 | a Weedon, Michael N4 aut |
700 | 1 | a Aulchenko, Yurii S4 aut |
700 | 1 | a Voight, Benjamin F4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Bergman, Richard N4 aut |
700 | 1 | a Bielinski, Suzette J4 aut |
700 | 1 | a Bonnefond, Amelie4 aut |
700 | 1 | a Bonnycastle, Lori L4 aut |
700 | 1 | a Borch-Johnsen, Knut4 aut |
700 | 1 | a Böttcher, Yvonne4 aut |
700 | 1 | a Brunner, Eric4 aut |
700 | 1 | a Buchanan, Thomas A4 aut |
700 | 1 | a Bumpstead, Suzannah J4 aut |
700 | 1 | a Cavalcanti-Proença, Christine4 aut |
700 | 1 | a Charpentier, Guillaume4 aut |
700 | 1 | a Chen, Yii-Der Ida4 aut |
700 | 1 | a Chines, Peter S4 aut |
700 | 1 | a Collins, Francis S4 aut |
700 | 1 | a Cornelis, Marilyn4 aut |
700 | 1 | a J Crawford, Gabriel4 aut |
700 | 1 | a Delplanque, Jerome4 aut |
700 | 1 | a Doney, Alex4 aut |
700 | 1 | a Egan, Josephine M4 aut |
700 | 1 | a Erdos, Michael R4 aut |
700 | 1 | a Firmann, Mathieu4 aut |
700 | 1 | a Forouhi, Nita G4 aut |
700 | 1 | a Fox, Caroline S4 aut |
700 | 1 | a Goodarzi, Mark O4 aut |
700 | 1 | a Graessler, Jürgen4 aut |
700 | 1 | a Hingorani, Aroon4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Jørgensen, Torben4 aut |
700 | 1 | a Kivimaki, Mika4 aut |
700 | 1 | a Kovacs, Peter4 aut |
700 | 1 | a Krohn, Knut4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a Lauritzen, Torsten4 aut |
700 | 1 | a Lévy-Marchal, Claire4 aut |
700 | 1 | a Mayor, Vladimir4 aut |
700 | 1 | a McAteer, Jarred B4 aut |
700 | 1 | a Meyre, David4 aut |
700 | 1 | a Mitchell, Braxton D4 aut |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a Morken, Mario A4 aut |
700 | 1 | a Narisu, Narisu4 aut |
700 | 1 | a Palmer, Colin N A4 aut |
700 | 1 | a Pakyz, Ruth4 aut |
700 | 1 | a Pascoe, Laura4 aut |
700 | 1 | a Payne, Felicity4 aut |
700 | 1 | a Pearson, Daniel4 aut |
700 | 1 | a Rathmann, Wolfgang4 aut |
700 | 1 | a Sandbaek, Annelli4 aut |
700 | 1 | a Sayer, Avan Aihie4 aut |
700 | 1 | a Scott, Laura J4 aut |
700 | 1 | a Sharp, Stephen J4 aut |
700 | 1 | a Sijbrands, Eric4 aut |
700 | 1 | a Singleton, Andrew4 aut |
700 | 1 | a Siscovick, David S4 aut |
700 | 1 | a Smith, Nicholas L4 aut |
700 | 1 | a Sparsø, Thomas4 aut |
700 | 1 | a Swift, Amy J4 aut |
700 | 1 | a Syddall, Holly4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Tönjes, Anke4 aut |
700 | 1 | a Tuomi, Tiinamaija4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Valle, Timo T4 aut |
700 | 1 | a Waeber, Gérard4 aut |
700 | 1 | a Walley, Andrew4 aut |
700 | 1 | a Waterworth, Dawn M4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Wichmann, H Erich4 aut |
700 | 1 | a Wilson, James F4 aut |
700 | 1 | a van Duijn, Cornelia4 aut |
700 | 1 | a Hu, Frank B4 aut |
700 | 1 | a Morris, Andrew D4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Hattersley, Andrew T4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Shuldiner, Alan R4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Bornstein, Stefan R4 aut |
700 | 1 | a Schwarz, Peter4 aut |
700 | 1 | a Williams, Gordon H4 aut |
700 | 1 | a Nathan, David M4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Marmot, Michael4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Mooser, Vincent4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Loos, Ruth J F4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Psaty, Bruce M4 aut |
700 | 1 | a Rotter, Jerome I4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Florez, Jose C4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Barroso, Inês4 aut |
700 | 1 | a Sladek, Robert4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Meigs, James B4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Watanabe, Richard M4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 42:2, s. 142-148q 42:2<142-148x 1061-4036x 1546-1718 |
856 | 4 | u https://cdr.lib.unc.edu/downloads/pr76fb134 |
856 | 4 | u http://dx.doi.org/10.1038/ng.521y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131527 |
856 | 4 8 | u https://doi.org/10.1038/ng.521 |
856 | 4 8 | u https://lup.lub.lu.se/record/1569874 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120004916 |
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