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WFRF:(Månsson L. K.)
 

Search: WFRF:(Månsson L. K.) > Dysfunction of Plat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003617naa a2200529 4500
001oai:gup.ub.gu.se/215450
003SwePub
008240528s2015 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2154502 URI
0247 a https://doi.org/10.1074/jbc.M115.6364982 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pituch, K. C.4 aut
2451 0a Dysfunction of Platelet-derived Growth Factor Receptor a (PDGFR alpha) Represses the Production of Oligodendrocytes from Arylsulfatase A-deficient Multipotential Neural Precursor Cells
264 1c 2015
520 a The membrane-bound receptor for platelet-derived growth factor A (PDGFR alpha) is crucial for controlling the production of oligodendrocytes (OLs) for myelination, but regulation of its activity during OL differentiation is largely unknown. We have examined the effect of increased sulfated content of galactosylceramides (sulfatides) on the regulation of PDGTR alpha in multipotential neural precursors (NPs) that are deficient in arylsulfatase A (ASA) activity. This enzyme is responsible for the lysosomal hydrolysis of sulfatides. We show that sulfatide accumulation significantly impacts the formation of OLs via deregulation of PDGFR alpha function. PDGFR alpha is less associated with detergent-resistant membranes in ASA-deficient cells and showed a significant decrease in AKT phosphorylation Rescue experiments with ASA showed a normalization of the ratio of long versus short sulfatides, restored PDGTRa levels, corrected its localization to detergent-resistant membranes, increased AKT phosphorylation, and normalized the production of OLs in ASA-deficient NPs. Moreover, our studies identified a novel mechanism that regulates the secretion of PDGFR alpha in NPs, in glial cells, and in the brain cortex via exosomal shedding. Our study provides a first step in understanding the role of sulfatides in regulating PDGFR alpha levels in OLs and its impact in myelination.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a CENTRAL-NERVOUS-SYSTEM
653 a SPINAL-CORD OLIGODENDROCYTES
653 a METACHROMATIC
653 a LEUKODYSTROPHY
653 a PROGENITOR CELLS
653 a MYELIN MEMBRANE
653 a SONIC HEDGEHOG
653 a LIPID
653 a RAFTS
653 a INTRACELLULAR TRAFFICKING
653 a MULTIVESICULAR ENDOSOMES
653 a RETICULOCYTE
653 a MATURATION
653 a Biochemistry & Molecular Biology
7001 a Moyano, A. L.4 aut
7001 a Lopez-Rosas, A.4 aut
7001 a Marottoli, F. M.4 aut
7001 a Li, G. N.4 aut
7001 a Hu, C. Q.4 aut
7001 a van Breemen, R.4 aut
7001 a Månsson, Jan-Eric,d 1946u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine4 aut0 (Swepub:gu)xmanja
7001 a Givogri, M. I.4 aut
7102 a Göteborgs universitetb Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin4 org
7730 t Journal of Biological Chemistryg 290:11, s. 7040-7053q 290:11<7040-7053x 0021-9258
8564 8u https://gup.ub.gu.se/publication/215450
8564 8u https://doi.org/10.1074/jbc.M115.636498

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