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Sökning: WFRF:(Nicholls David) > Aldosterone Does No...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004443naa a2200469 4500
001oai:DiVA.org:liu-135708
003SwePub
008170317s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1357082 URI
0247 a https://doi.org/10.1161/JAHA.116.0041192 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pitts, Reynariau VA Medical Centre, CO USA; University of Colorado, CO USA4 aut
2451 0a Aldosterone Does Not Predict Cardiovascular Events Following Acute Coronary Syndrome in Patients Initially Without Heart Failure
264 1b WILEY-BLACKWELL,c 2017
338 a electronic2 rdacarrier
500 a Funding Agencies|F. Hoffmann-La Roche
520 a Background- Aldosterone may have adverse effects in the myocardium and vasculature. Treatment with an aldosterone antagonist reduces cardiovascular risk in patients with acute myocardial infarction complicated by heart failure (HF) and left ventricular systolic dysfunction. However, most patients with acute coronary syndrome do not have advanced HF. Among such patients, it is unknown whether aldosterone predicts cardiovascular risk. Methods and Results- To address this question, we examined data from the dal-OUTCOMES trial that compared the cholesteryl ester transfer protein inhibitor dalcetrapib with placebo, beginning 4 to 12 weeks after an index acute coronary syndrome. Patients with New York Heart Association class II (with LVEF amp;lt; 40%), III, or IV HF were excluded. Aldosterone was measured at randomization in 4073 patients. The primary outcome was a composite of coronary heart disease death, nonfatal myocardial infarction, stroke, hospitalization for unstable angina, or resuscitated cardiac arrest. Hospitalization for HF was a secondary endpoint. Over a median follow-up of 37 months, the primary outcome occurred in 366 patients (9.0%), and hospitalization for HF occurred in 72 patients (1.8%). There was no association between aldosterone and either the time to first occurrence of a primary outcome (hazard ratio for doubling of aldosterone 0.92, 95% confidence interval 0.78-1.09, P=0.34) or hospitalization for HF (hazard ratio 1.38, 95% CI 0.96-1.99, P=0.08) in Cox regression models adjusted for covariates. Conclusions- In patients with recent acute coronary syndrome but without advanced HF, aldosterone does not predict major cardiovascular events.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a acute coronary syndrome; aldosterone; morbidity/mortality
7001 a Gunzburger, Eliseu University of Colorado, CO USA4 aut
7001 a Ballantyne, Christie M.u Baylor Coll Med, TX 77030 USA4 aut
7001 a Barter, Philip J.u University of New South Wales, Australia4 aut
7001 a Kallend, Davidu Medicines Co, Switzerland4 aut
7001 a Leiter, Lawrence A.u University of Toronto, Canada; University of Toronto, Canada4 aut
7001 a Leitersdorf, Eranu Hadassah Hebrew University, Israel4 aut
7001 a Nicholls, Stephen J.u University of Adelaide, Australia; University of Adelaide, Australia4 aut
7001 a Shah, Prediman K.u Cedars Sinai Heart Institute, CA USA4 aut
7001 a Tardif, Jean-Claudeu University of Montreal, Canada4 aut
7001 a Olsson, Anders,d 1940-u Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken4 aut0 (Swepub:liu)andol21
7001 a McMurray, John J. V.u University of Glasgow, Scotland4 aut
7001 a Kittelson, Johnu University of Colorado, CO USA4 aut
7001 a Schwartz, Gregory G.u VA Medical Centre, CO USA; University of Colorado, CO USA4 aut
7102 a VA Medical Centre, CO USA; University of Colorado, CO USAb University of Colorado, CO USA4 org
7730 t Journal of the American Heart Associationd : WILEY-BLACKWELLg 6:1q 6:1x 2047-9980
8564 u https://liu.diva-portal.org/smash/get/diva2:1082697/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-135708
8564 8u https://doi.org/10.1161/JAHA.116.004119

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