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Influence of the sp...
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Pauksen, KarlisUppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
(författare)
Influence of the specific T cell response on seroconversion after measles vaccination in autologous bone marrow transplant patients
- Artikel/kapitelEngelska1996
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LIBRIS-ID:oai:DiVA.org:uu-55268
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55268URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1954655URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Six patients who were seronegative to measles after autologous bone marrow transplantation (ABMT) were vaccinated with a live attenuated measles vaccine. The specific T helper cell response was studied by measuring lymphocyte proliferation induced by measles antigen and B cell response by measles specific IgG by ELISA. Blood samples were drawn before, at 1-3 months, and at 1 year after vaccination. It was found that a pre-existing T cell response correlated with an impaired B cell response 1 year after vaccination (r = 0.83, P = 0.04), whereas no correlation was found between IgG titers before vaccination and IgG titer increase, or T cell response after vaccination. Furthermore, there was a transient negative correlation between the T cell response at 1-3 months after vaccination and the T cell response before vaccination (r = -0.90, P = 0.04) that became positive at 1 year after vaccination (r = 0.90, P = 0.02). In conclusion, in patients seronegative to measles who were revaccinated with measles vaccine after ABMT, a pre-existing T cell response correlated with an impaired B cell response, while pre-existing low-level IgG antibodies had no significant influence on the IgG titer rise. A sustained T cell response to measles antigen before vaccination may thus be one possible explanation for measles vaccine failure in ABMT patients.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Linde, A.
(författare)
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Lönnerholm, GudmarUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Lönnerholm
(författare)
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Ljungman, P.Karolinska Institutet
(författare)
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Sjölin, JanUppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Bone Marrow Transplantation18:5, s. 969-9730268-33691476-5365
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