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Microneurography as a tool to study the function of individual C-fiber afferents in humans: responses from nociceptors, thermoreceptors, and mechanoreceptors
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- Ackerley, Rochelle, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Watkins, Roger H., 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
- (creator_code:org_t)
- American Physiological Society, 2018
- 2018
- English.
- In: Journal of Neurophysiology. - : American Physiological Society. - 0022-3077 .- 1522-1598. ; 120:6, s. 2834-2846
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The technique of microneurography-recording neural traffic from nerves in awake humans-has provided us with unrivaled insights into afferent and efferent processes in the peripheral nervous system for over 50 years. We review the use of microneurography to study single C-fiber afferents and provide an overview of the knowledge gained, with views to future investigations. C-fibers have slowly conducting, thin-diameter, unmyelinated axons and make up the majority of the fibers in peripheral nerves (similar to 80%). With the use of microneurography in humans, C-fiber afferents have been differentiated into discrete subclasses that encode specific qualities of stimuli on the skin, and their functional roles have been investigated. Afferent somatosensory information provided by C-fibers underpins various positive and negative affective sensations from the periphery, including mechanical, thermal, and chemical pain (C-nociceptors), temperature (C-thermoreceptors), and positive affective aspects of touch (C-tactile afferents). Insights from microneurographic investigations have revealed the complexity of the C-fiber system, methods for delineating fundamental C-fiber populations in a translational manner, how C-fiber firing can be used to identify nerve deficits in pathological states, and how the responses from C-fibers may be modified to change sensory percepts, including decreasing pain. Understanding these processes may lead to future medical interventions to diagnose and treat C-fiber dysfunction. NEW & NOTEWORTHY The technique of microneurography allows us to directly investigate the functional roles of single C-fiber afferents in awake human beings. Here we outline and discuss the current field of C-fiber research on this heterogeneous population of afferents in healthy subjects, in pathological states, and from a translational perspective. We cover C-fibers encoding touch, temperature, and pain and provide perspectives on the future of C-fiber microneurography investigations in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- C-fiber
- mechanoreceptor
- microneurography
- nociception
- pain
- temperature
- touch
- mechano-insensitive nociceptors
- unmyelinated tactile afferents
- velocity recovery cycles
- human-skin
- electrical-stimulation
- intraneural microstimulation
- innervation territories
- conduction-velocity
- heat stimulation
- low-temperature
- Neurosciences & Neurology
- Physiology
- hmelz m
- 1995
- experimental brain research
- v104
- p331
- hmidt r
- 1995
- journal of neuroscience
- v15
- p333
- hmelz m
- 1994
- journal of physiology-london
- v480
- p389
Publication and Content Type
- ref (subject category)
- art (subject category)
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