L773:0271 3683
Sökning: L773:0271 3683 > Retinal glial cell ...
- Agardh, ElisabetLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine (författare)
Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes
- Artikel/kapitelEngelska2001
Förlag, utgivningsår, omfång ...
- 2009-07-02
- Informa UK Limited,2001
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- LIBRIS-ID:oai:lup.lub.lu.se:840c9a7b-7cf7-41cd-8b12-6ca3a919f188
- https://lup.lub.lu.se/record/1124865URI
- https://doi.org/10.1076/ceyr.23.4.276.5459DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- PURPOSE: To study whether diabetes could influence glial cells, retinal neurons, and pigment epithelial cells and if so, to evaluate whether any changes could be influenced by aminoguanidine (AG) or probucol (PB). METHODS: Streptozocin (STZ)-induced diabetic male Wistar rats and age-matched control rats were fed a normal diet, addition of AG in the drinking water (0.5 g/l for diabetic and 1.0 g/l for control rats) or PB in the pellets (1 % w/w) for one or six months. Paraffin embedded retinal sections were incubated in the primary antibodies GFAP, calbindin, RPE65, and Hu, for glial, horizontal, pigment epithelial, and ganglion cells, respectively, and in fluorescent secondary antibodies. RESULTS: One month after STZ injection, GFAP immunoreactivity was sparse, but after six months it was prominent in glial cells in 5/5 diabetic and 1/7 control retinas (p = 0.015). Neither AG, nor PB influenced this immunoreactivity. Numbers of retinal pigment epithelial cells and cells in the ganglion cell layer, were similar at one and six months of diabetes. By time, the number of horizontal cells decreased (p < 0.001) and branching and numbers of their terminals were reduced (p < 0.001). CONCLUSION: Diabetes for six months resulted in increased glial cell immunoreactivity, and by age, horizontal cell numbers and branching of their terminals decreased, morphological patterns that were unaffected by AG or PB. The numbers of retinal pigment epithelial cells and cells in the ganglion cell layer were unaffected both by age and diabetes.
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- Bruun, AnithaLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)oft-abr (författare)
- Agardh, Carl-DavidLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-cag (författare)
- Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten (creator_code:org_t)
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- Ingår i:Current Eye Research: Informa UK Limited23:4, s. 276-2840271-36831460-2202
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