Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study

Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus : a retrospective study

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a life-threatening respiratory disease with a high case fatality rate; however, its risk factors remain unclear. We aimed to explore the influence of demographic factors, clinical manifestations and underlying comorbidities on mortality in MERS-CoV patients. Retrospective chart reviews were performed to identify all laboratory-confirmed cases of MERS-COV infection in Saudi Arabia that were reported to the Ministry of Health of Saudi Arabia between 23 April 2014 and 7 June 2016. Statistical analyses were conducted to assess the effect of sex, age, clinical presentation and comorbidities on mortality from MERS-CoV. A total of 281 confirmed MERS-CoV cases were identified: 167 (59.4%) patients were male and 55 (20%) died. Mortality predominantly occurred among Saudi nationals and older patients and was significantly associated with respiratory failure and shortness of breath. Of the 281 confirmed cases, 160 (56.9%) involved comorbidities, wherein diabetes mellitus, hypertension, ischemic heart disease, congestive heart failure, end-stage renal disease and chronic kidney disease were significantly associated with mortality from MERS-CoV and two or three comorbidities significantly affected the fatality rates from MERS-CoV. The findings of this study show that old age and the existence of underlying comorbidities significantly increase mortality from MERS-CoV.

Aleanizy, F. S. (författare)
Mohamed, R. Ali El Hadi (författare)
Alanazi, M. S. (författare)
Mohamed, NahlaUmeå universitet,Virologi,College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 12484, Saudi Arabia(Swepub:umu)namo0017 (författare)
Alrasheed, M. M. (författare)
Abanmy, N. (författare)
Alhawassi, T. (författare)
Umeå universitetVirologi (creator_code:org_t)

Ingår i:Epidemiology and Infection: Cambridge University Press1470950-26881469-4409

Av författaren/redakt...: Alqahtani, F. Y.; Aleanizy, F. S.; Mohamed, R. Ali ...; Alanazi, M. S.; Mohamed, Nahla; Alrasheed, M. M.; visa fler...; Abanmy, N.; Alhawassi, T.; visa färre...

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