Sökning: L773:1469 445X OR L773:0958 0670 > (2015-2019) > Integrin αVβ3 can s...
Fältnamn | Indikatorer | Metadata |
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000 | 05055naa a2200505 4500 | |
001 | oai:DiVA.org:uu-356075 | |
003 | SwePub | |
008 | 180713s2018 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:7815ff2c-86b0-4f68-b201-de7db8f98ffe | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3560752 URI |
024 | 7 | a https://doi.org/10.1113/EP0869022 DOI |
024 | 7 | a https://lup.lub.lu.se/record/7815ff2c-86b0-4f68-b201-de7db8f98ffe2 URI |
040 | a (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Liden, Åsau Univ Bergen, Dept Biomed, Bergen, Norway,University of Bergen4 aut |
245 | 1 0 | a Integrin αVβ3 can substitute for collagen‐binding β1‐integrins in vivo to maintain a homeostatic interstitial fluid pressure |
264 | 1 | c 2018 |
338 | a electronic2 rdacarrier | |
500 | a WoS title: Integrin alpha(V)beta(3) can substitute for collagen-binding beta(1)-integrins in vivo to maintain a homeostatic interstitial fluid pressurel | |
520 | a Accumulated data indicate that cell‐mediated contraction of reconstituted collagenous gels in vitro can serve as a model for cell‐mediated control of interstitial fluid pressure (PIF) in vivo. A central role for collagen‐binding β1‐integrins in both processes has been established. Furthermore, integrin αVβ3 takes over the role of collagen‐binding β1‐integrins in mediating contraction after perturbations of collagen‐binding β1‐integrins in vitro. Integrin αVβ3 is also instrumental for normalization of dermal PIF that has been lowered due to mast cell degranulation with compound 48/80 (C48/80) in vivo. Here we demonstrate a role of integrin αVβ3 in maintaining a long term homeostatic dermal PIF in mice lacking the collagen‐binding integrin α11β1 (α11−/− mice). Measurements of PIF were performed after circulatory arrest. Furthermore, cell‐mediated integrin αVβ3‐directed contraction of collagenous gels in vitro depends on free access to a collagen site known to bind several extracellular matrix (ECM) proteins that form substrates for αVβ3‐directed cell attachment, such as fibronectin and fibrin. A streptococcal collagen‐binding protein, CNE, specifically binds to and blocks this site on the collagen triple helix. Here we show that whereas CNE perturbed αVβ3‐directed and platelet‐derived growth factor BB‐induced normalization of dermal PIF after C48/80, it did not affect αVβ3‐dependent maintenance of a homeostatic dermal PIF. These data imply that dynamic modification of the ECM structure is needed during acute patho‐physiological modulations of PIF but not for long‐term maintenance of a homeostatic PIF. Our data thus show that collagen‐binding β1‐integrins, integrin αVβ3 and ECM structure are potential targets for novel therapy aimed at modulating oedema formation and hypovolemic shock during anaphylaxis. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a contraction | |
653 | a extracellular matrix | |
653 | a microcirculation | |
653 | a contraction | |
653 | a extracellular matrix | |
653 | a microcirculation | |
700 | 1 | a Karlsen, Tine Veronikau Univ Bergen, Dept Biomed, Bergen, Norway,University of Bergen4 aut |
700 | 1 | a Guss, Bengtu Swedish University of Agricultural Sciences4 aut |
700 | 1 | a Reed, Rolf K.u Univ Bergen, Dept Biomed, Bergen, Norway; Univ Bergen, Ctr Canc Biomarkers CCBIO, Bergen, Norway,University of Bergen4 aut |
700 | 1 | a Rubin, Kristoferu Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Lund Univ, Dept Lab Med, Translat Canc Res, Sweden,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-krn |
710 | 2 | a Univ Bergen, Dept Biomed, Bergen, Norwayb University of Bergen4 org |
773 | 0 | t Experimental Physiologyg 103:5, s. 629-634q 103:5<629-634x 0958-0670x 1469-445X |
856 | 4 | u https://doi.org/10.1113/EP086902y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1232959/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1113/EP086902x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356075 |
856 | 4 8 | u https://doi.org/10.1113/EP086902 |
856 | 4 8 | u https://lup.lub.lu.se/record/7815ff2c-86b0-4f68-b201-de7db8f98ffe |
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