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Sökning: L773:1878 5492 OR L773:0966 3274 > (2010-2014) > Imaging the in vivo...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02783naa a2200361 4500 | |
| 001 | oai:DiVA.org:uu-216763 | |
| 003 | SwePub | |
| 008 | 140124s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2167632 URI |
| 024 | 7 | a https://doi.org/10.1016/j.trim.2013.09.0092 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Berglund, Davidu Uppsala universitet,Klinisk immunologi,Transplantationskirurgi4 aut0 (Swepub:uu)davbe892 |
| 245 | 1 0 | a Imaging the in vivo fate of human T cells following transplantation in immunoincompetent mice - Implications for clinical cell therapy trials |
| 264 | 1 | b Elsevier BV,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Many forms of adoptive T cell therapy are on the verge of being translated to the clinic. To gain further insight in their immunomodulating functions and to optimize future clinical trials it is essential to develop techniques to study their homing capacity. CD4+ T cells were labeled using [In-111]oxine, and the radioactive uptake was determined in vitro before intravenous injection in immunodeficient mice. In vivo biodistribution of [In-111] oxine-labeled cells or tracer alone was subsequently measured by mu SPECT/CT and organ distribution. CD4+ T cells incorporated [In-111]oxine with higher labeling yield using Ringer-Acetate compared to 0.9% NaCl. Cellular viability after labeling with [In-111]oxine was not compromised using less than 0.4 MBq/million cells. After intravenous infusion CD4+ T cells preferentially homed to the liver (p < 0.01) and spleen (p < 0.05). This study presents a protocol for labeling of T cells by [In-111]oxine with preserved viability and in vivo tracking by SPECT for up to 8 days, which can easily be translated to clinical cell therapy trials. | |
| 653 | a T cell | |
| 653 | a In vivo imaging | |
| 653 | a Cell therapy | |
| 653 | a SPECT/CT | |
| 700 | 1 | a Karlsson, Marieu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)makar254 |
| 700 | 1 | a Palanisamy, Senthilkumaru Uppsala universitet,Plattformen för preklinisk PET4 aut |
| 700 | 1 | a Carlsson, Björnu Uppsala universitet,Klinisk immunologi4 aut |
| 700 | 1 | a Korsgren, Olleu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)ollekors |
| 700 | 1 | a Eriksson, Olofu Uppsala universitet,Plattformen för preklinisk PET4 aut0 (Swepub:uu)oloer586 |
| 710 | 2 | a Uppsala universitetb Klinisk immunologi4 org |
| 773 | 0 | t Transplant Immunologyd : Elsevier BVg 29:1-4, s. 105-108q 29:1-4<105-108x 0966-3274x 1878-5492 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216763 |
| 856 | 4 8 | u https://doi.org/10.1016/j.trim.2013.09.009 |
Hitta mer i SwePub
- Av författaren/redakt...
- Berglund, David
- Karlsson, Marie
- Palanisamy, Sent ...
- Carlsson, Björn
- Korsgren, Olle
- Eriksson, Olof
- Artiklar i publikationen
- Transplant Immun ...
- Av lärosätet
- Uppsala universitet
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