How many human proteoforms are there?

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Fältnamn	Indikatorer	Metadata
000		04379naa a2200913 4500
001		oai:DiVA.org:kth-223782
003		SwePub
008		180307s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2237822 URI
024	7	a https://doi.org/10.1038/NCHEMBIO.25762 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Aebersold, Ruedi4 aut
245	1 0	a How many human proteoforms are there?
264	1	b NATURE PUBLISHING GROUP,c 2018
338		a print2 rdacarrier
500		a QC 2018307
520		a Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA-and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease. We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?" We also explore prospects for improving measurements to better regularize protein-level biology and efficiently associate PTMs to function and phenotype.
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
700	1	a Agar, Jeffrey N.4 aut
700	1	a Amster, I. Jonathan4 aut
700	1	a Baker, Mark S.4 aut
700	1	a Bertozzi, Carolyn R.4 aut
700	1	a Boja, Emily S.4 aut
700	1	a Costello, Catherine E.4 aut
700	1	a Cravatt, Benjamin F.4 aut
700	1	a Fenselau, Catherine4 aut
700	1	a Garcia, Benjamin A.4 aut
700	1	a Ge, Ying4 aut
700	1	a Gunawardena, Jeremy4 aut
700	1	a Hendrickson, Ronald C.4 aut
700	1	a Hergenrother, Paul J.4 aut
700	1	a Huber, Christian G.4 aut
700	1	a Ivanov, Alexander R.4 aut
700	1	a Jensen, Ole N.4 aut
700	1	a Jewett, Michael C.4 aut
700	1	a Kelleher, Neil L.4 aut
700	1	a Kiessling, Laura L.4 aut
700	1	a Krogan, Nevan J.4 aut
700	1	a Larsen, Martin R.4 aut
700	1	a Loo, Joseph A.4 aut
700	1	a Loo, Rachel R. Ogorzalek4 aut
700	1	a Lundberg, Emmau KTH,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Genet, Stanford, CA 94305 USA4 aut0 (Swepub:kth)u12bylj1
700	1	a MacCoss, Michael J.4 aut
700	1	a Mallick, Parag4 aut
700	1	a Mootha, Vamsi K.4 aut
700	1	a Mrksich, Milan4 aut
700	1	a Muir, Tom W.4 aut
700	1	a Patrie, Steven M.4 aut
700	1	a Pesavento, James J.4 aut
700	1	a Pitteri, Sharon J.4 aut
700	1	a Rodriguez, Henry4 aut
700	1	a Saghatelian, Alan4 aut
700	1	a Sandoval, Wendy4 aut
700	1	a Schluter, Hartmut4 aut
700	1	a Sechi, Salvatore4 aut
700	1	a Slavoff, Sarah A.4 aut
700	1	a Smith, Lloyd M.4 aut
700	1	a Snyder, Michael P.4 aut
700	1	a Thomas, Paul M.4 aut
700	1	a Uhlen, Mathias4 aut
700	1	a Van Eyk, Jennifer E.4 aut
700	1	a Vidal, Marc4 aut
700	1	a Walt, David R.4 aut
700	1	a White, Forest M.4 aut
700	1	a Williams, Evan R.4 aut
700	1	a Wohlschlager, Therese4 aut
700	1	a Wysocki, Vicki H.4 aut
700	1	a Yates, Nathan A.4 aut
700	1	a Young, Nicolas L.4 aut
700	1	a Zhang, Bing4 aut
710	2	a KTHb Science for Life Laboratory, SciLifeLab4 org
773	0	t Nature Chemical Biologyd : NATURE PUBLISHING GROUPg 14:3, s. 206-214q 14:3<206-214x 1552-4450x 1552-4469
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-223782
856	4 8	u https://doi.org/10.1038/NCHEMBIO.2576

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Av författaren/redakt...: Aebersold, Ruedi; Agar, Jeffrey N.; Amster, I. Jonat ...; Baker, Mark S.; Bertozzi, Caroly ...; Boja, Emily S.; visa fler...; Costello, Cather ...; Cravatt, Benjami ...; Fenselau, Cather ...; Garcia, Benjamin ...; Ge, Ying; Gunawardena, Jer ...; Hendrickson, Ron ...; Hergenrother, Pa ...; Huber, Christian ...; Ivanov, Alexande ...; Jensen, Ole N.; Jewett, Michael ...; Kelleher, Neil L ...; Kiessling, Laura ...; Krogan, Nevan J.; Larsen, Martin R ...; Loo, Joseph A.; Loo, Rachel R. O ...; Lundberg, Emma; MacCoss, Michael ...; Mallick, Parag; Mootha, Vamsi K.; Mrksich, Milan; Muir, Tom W.; Patrie, Steven M ...; Pesavento, James ...; Pitteri, Sharon ...; Rodriguez, Henry; Saghatelian, Ala ...; Sandoval, Wendy; Schluter, Hartmu ...; Sechi, Salvatore; Slavoff, Sarah A ...; Smith, Lloyd M.; Snyder, Michael ...; Thomas, Paul M.; Uhlen, Mathias; Van Eyk, Jennife ...; Vidal, Marc; Walt, David R.; White, Forest M.; Williams, Evan R ...; Wohlschlager, Th ...; Wysocki, Vicki H ...; Yates, Nathan A.; Young, Nicolas L ...; Zhang, Bing; visa färre...

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