WFRF:(Agren Göran)
Search: WFRF:(Agren Göran) > (2000-2004) > Postmenopausal brea...
- 3 of 3
- Previous record
- Next record
- To hitlist
Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin and SHBG (Sweden)
-
- Manjer, Jonas (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
- Johansson, R (author)
-
- Berglund, Göran (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
- show more...
- Kaaks, R (author)
- Agren, A (author)
- Lenner, P (author)
- show less...
- (creator_code:org_t)
- 2003
- 2003
- English.
- In: Cancer Causes and Control. - 1573-7225. ; 14:7, s. 599-607
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Objective: High levels of sex steroid hormones and prolactin have been suggested to enhance breast cancer development. Low levels of SHBG may indicate high levels of (bio-available) steroid hormones. The present study investigates whether high levels of sex steroid hormones and prolactin, and/or low levels of SHBG, are associated with high breast cancer risk. Methods: Blood samples were collected in about 65,000 women participating in two population-based prospective cohort studies in Sweden. Follow-up yielded 173 postmenopausal breast cancer cases who had not been exposed to HRT. Levels of estrone, estradiol, SHBG, FSH, prolactin, testosterone, androstenedione and DHEAs were analysed in cases and 438 controls. Logistic regression analysis yielded odds ratios (ORs), with 95% confidence intervals, adjusted for potential confounders. Results: The risk of breast cancer was associated with the highest versus lowest quartiles of estrone, OR: 2.58 (1.50 - 4.44), estradiol (dichotomised: high versus low) (1.73: 1.04 - 2.88), and testosterone (1.87: 1.08 - 3.25). High risks, although not statistically significant, were seen for androstenedione (1.58: 0.92 - 2.72) and DHEAs ( 1.62: 0.89 - 2.72). No strong associations were seen between SHBG or prolactin and risk of breast cancer. Conclusions: High levels of estrone, estradiol, testosterone, and possibly androstenedione and DHEAs, in postmenopausal women are associated with a high risk of subsequent breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- SHBG
- sex steroid hormones
- breast cancer
- prolactin
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Cancer Causes and Control (Search for host publication in LIBRIS)
To the university's database
- 3 of 3
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Manjer, Jonas
- Johansson, R
- Berglund, Göran
- Janzon, Lars
- Kaaks, R
- Agren, A
- show more...
- Lenner, P
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Cancer Causes an ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
