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Modifiable risk factors for permanent pacemaker after transcatheter aortic valve implantation: CONDUCT registry

Rudolph, Tanja (författare)
Cologne Univ, Germany; Ruhr Univ Bochum, Germany
Droppa, Michal (författare)
Univ Hosp Tubingen, Germany
Baan, Jan (författare)
Univ Amsterdam, Netherlands
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Nielsen, Niels Erik (författare)
Region Östergötland, Kardiologiska kliniken US
Baranowski, Jacek (författare)
Region Östergötland, Kardiologiska kliniken US
Hachaturyan, Violetta (författare)
Inst Pharmacol & Prevent Med, Germany
Kurucova, Jana (författare)
Edwards Lifesciences, Czech Republic
Hack, Luis (författare)
Cologne Univ, Germany
Bramlage, Peter (författare)
Inst Pharmacol & Prevent Med, Germany
Geisler, Tobias (författare)
Univ Hosp Tubingen, Germany
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 (creator_code:org_t)
2023-02-07
2023
Engelska.
Ingår i: Open heart. - : BMJ PUBLISHING GROUP. - 2053-3624. ; 10:1
Relaterad länk:
https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective The onset of new conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) is still a relevant adverse event. The main objective of this registry was to identify modifiable procedural risk factors for an improved outcome (lower rate of PPI) after TAVI in patients at high risk of PPI.Methods Patients from four European centres receiving a balloon-expandable TAVI (Edwards SAPIEN 3/3 Ultra) and considered at high risk of PPI (pre-existing conduction disturbance, heavily calcified left ventricular outflow tract or short membranous septum) were prospectively enrolled into registry.Results A total of 300 patients were included: 42 (14.0%) required PPI after TAVI and 258 (86.0%) did not. Patients with PPI had a longer intensive care unit plus intermediate care stay (65.7 vs 16.3 hours, p < 0.001), general ward care stay (6.9 vs 5.3 days, p=0.004) and later discharge (8.6 vs 5.0 days, p < 0.001). Of the baseline variables, only pre-existing right bundle branch block at baseline (OR 6.8, 95% CI 2.5 to 18.1) was significantly associated with PPI in the multivariable analysis. Among procedure-related variables, oversizing had the highest impact on the rate of PPI: higher than manufacturer-recommended sizing, mean area oversizing as well as the use of the 29 mm valve (OR 3.4, 95% CI 1.4 to 8.5, p=0.008) all were significantly associated with PPI. Rates were higher with the SAPIEN 3 (16.1%) vs SAPIEN 3 Ultra (8.5%), although not statistically significant but potentially associated with valve sizing. Implantation depth and postdelivery balloon dilatation also tended to affect PPI rates but without a statistical significance.Conclusion Valve oversizing is a strong procedure-related risk factor for PPI following TAVI. The clinical impact of the valve type (SAPIEN 3), implantation depth, and postdelivery balloon dilatation did not reach significance and may reflect already refined procedures in the participating centres, giving attention to these avoidable risk factors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

aortic valve stenosis; transcatheter aortic valve replacement; pacemaker; artificial

Publikations- och innehållstyp

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