SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Carlström Karl)
 

Sökning: WFRF:(Carlström Karl) > Therapeutic efficac...

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Carlström, Karl E. (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Ewing, Ewoud (författare)
Karolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Granqvist, Mathias (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
visa fler...
Gyllenberg, Alexandra (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Aeinehband, Shahin (författare)
Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Enoksson, Sara Lind (författare)
Karolinska Institutet,Department of Clinical Immunology Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden
Checa, Antonio (författare)
Karolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Badam, Tejaswi (författare)
Linköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Department of Physics, Chemistry & Biology (IFM), Bioinformatics, Linköping University, Sweden,Translationell Bioinformatik, Translational Bioinformatics,Bioinformatik,Tekniska fakulteten,Univ Skovde, Sweden
Huang, Jesse (författare)
Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Gomez-Cabrero, David (författare)
Karolinska Institutet,Translational Bioinformatics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Publica de Nevarra (UPNA), IdiSNA, Pamplona, Spain,Univ Publ Nevarra UPNA, Spain
Gustafsson, Mika (författare)
Linköpings universitet,Bioinformatik,Tekniska fakulteten
Al Nimer, Faiez (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Wheelock, Craig E. (författare)
Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Kockum, Ingrid (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Olsson, Tomas (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Jagodic, Maja (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Piehl, Fredrik (författare)
Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
visa färre...
 (creator_code:org_t)
2019-07-12
2019
Engelska.
Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10:1, s. 1-13
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://his.diva-por... (primary) (Raw object)
https://www.nature.c...
https://liu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but its precise therapeutic mechanisms of action remain elusive. Here we show impact of DMF on circulating monocytes and T cells in a prospective longitudinal RRMS patient cohort. DMF increases the level of oxidized isoprostanes in peripheral blood. Other observed changes, including methylome and transcriptome profiles, occur in monocytes prior to T cells. Importantly, monocyte counts and monocytic ROS increase following DMF and distinguish patients with beneficial treatment-response from non-responders. A single nucleotide polymorphism in the ROS-generating NOX3 gene is associated with beneficial DMF treatment-response. Our data implicate monocyte-derived oxidative processes in autoimmune diseases and their treatment, and identify NOX3 genetic variant, monocyte counts and redox state as parameters potentially useful to inform clinical decisions on DMF therapy of RRMS.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

placebo-controlled phase-3
TH17 cell-differentiation
regulatory T-cells
oxidative stress
hydrogen-peroxide
redox regulation
NRF2 pathway
oral BG-12
arthritis
suppression
Bioinformatik
Bioinformatics

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy