WFRF:(Carlström Karl)
Sökning: WFRF:(Carlström Karl) > Therapeutic efficac...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07100naa a2200769 4500 | |
| 001 | oai:DiVA.org:his-17478 | |
| 003 | SwePub | |
| 008 | 190725s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:141347206 | |
| 009 | oai:DiVA.org:liu-159141 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-174782 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-019-11139-32 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1413472062 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1591412 URI |
| 040 | a (SwePub)hisd (SwePub)kid (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Carlström, Karl E.u Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 245 | 1 0 | a Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes |
| 264 | c 2019-07-12 | |
| 264 | 1 | b Nature Publishing Group,c 2019 |
| 338 | a electronic2 rdacarrier | |
| 500 | a CC BY 4.0 | |
| 500 | a Funding Agencies|Swedish Medical Research Council [2017-03054]; Stockholm County [20170216]; Biogen; Hjarnfonden; NEURO Forbundet; Karolinska Thematic Center in Inflammation | |
| 520 | a Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but its precise therapeutic mechanisms of action remain elusive. Here we show impact of DMF on circulating monocytes and T cells in a prospective longitudinal RRMS patient cohort. DMF increases the level of oxidized isoprostanes in peripheral blood. Other observed changes, including methylome and transcriptome profiles, occur in monocytes prior to T cells. Importantly, monocyte counts and monocytic ROS increase following DMF and distinguish patients with beneficial treatment-response from non-responders. A single nucleotide polymorphism in the ROS-generating NOX3 gene is associated with beneficial DMF treatment-response. Our data implicate monocyte-derived oxidative processes in autoimmune diseases and their treatment, and identify NOX3 genetic variant, monocyte counts and redox state as parameters potentially useful to inform clinical decisions on DMF therapy of RRMS. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 653 | a placebo-controlled phase-3 | |
| 653 | a TH17 cell-differentiation | |
| 653 | a regulatory T-cells | |
| 653 | a oxidative stress | |
| 653 | a hydrogen-peroxide | |
| 653 | a redox regulation | |
| 653 | a NRF2 pathway | |
| 653 | a oral BG-12 | |
| 653 | a arthritis | |
| 653 | a suppression | |
| 653 | a Bioinformatik | |
| 653 | a Bioinformatics | |
| 700 | 1 | a Ewing, Ewoudu Karolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Granqvist, Mathiasu Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Gyllenberg, Alexandrau Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Aeinehband, Shahinu Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Enoksson, Sara Lindu Karolinska Institutet,Department of Clinical Immunology Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden4 aut |
| 700 | 1 | a Checa, Antoniou Karolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Badam, Tejaswiu Linköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Department of Physics, Chemistry & Biology (IFM), Bioinformatics, Linköping University, Sweden,Translationell Bioinformatik, Translational Bioinformatics,Bioinformatik,Tekniska fakulteten,Univ Skovde, Sweden4 aut0 (Swepub:liu)tejba58 |
| 700 | 1 | a Huang, Jesseu Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Gomez-Cabrero, Davidu Karolinska Institutet,Translational Bioinformatics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Publica de Nevarra (UPNA), IdiSNA, Pamplona, Spain,Univ Publ Nevarra UPNA, Spain4 aut |
| 700 | 1 | a Gustafsson, Mikau Linköpings universitet,Bioinformatik,Tekniska fakulteten4 aut0 (Swepub:liu)mikgu75 |
| 700 | 1 | a Al Nimer, Faiezu Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Wheelock, Craig E.u Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden4 aut |
| 700 | 1 | a Kockum, Ingridu Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Olsson, Tomasu Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Jagodic, Majau Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Piehl, Fredriku Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut |
| 710 | 2 | a Karolinska Institutetb Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden4 org |
| 773 | 0 | t Nature Communicationsd : Nature Publishing Groupg 10:1, s. 1-13q 10:1<1-13x 2041-1723 |
| 856 | 4 | u https://doi.org/10.1038/s41467-019-11139-3y Fulltext |
| 856 | 4 | u https://his.diva-portal.org/smash/get/diva2:1338916/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.nature.com/articles/s41467-019-11139-3.pdf |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1339662/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17478 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-019-11139-3 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141347206 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159141 |
Hitta mer i SwePub
- Av författaren/redakt...
- Carlström, Karl ...
- Ewing, Ewoud
- Granqvist, Mathi ...
- Gyllenberg, Alex ...
- Aeinehband, Shah ...
- Enoksson, Sara L ...
- visa fler...
- Checa, Antonio
- Badam, Tejaswi
- Huang, Jesse
- Gomez-Cabrero, D ...
- Gustafsson, Mika
- Al Nimer, Faiez
- Wheelock, Craig ...
- Kockum, Ingrid
- Olsson, Tomas
- Jagodic, Maja
- Piehl, Fredrik
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Hematologi
- Artiklar i publikationen
- Nature Communica ...
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
