Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells

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Fältnamn	Indikatorer	Metadata
000		03158naa a2200445 4500
001		oai:DiVA.org:uu-102181
003		SwePub
008		090505s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:118005331
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1021812 URI
024	7	a https://doi.org/10.1038/jid.2008.2062 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1180053312 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Skoog, Tiinau Karolinska Institutet4 aut
245	1 0	a Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells
264	1	b Elsevier BV,c 2009
338		a print2 rdacarrier
520		a In the skin, expression of several matrix metalloproteinases (MMPs) occurs in response to tissue injury, tumorigenesis, angiogenesis, apoptosis, and inflammation. The recently cloned MMP-21 has been implicated in skin development and various epithelial cancers. In this study, we found that it is also expressed by differentiated keratinocytes (KCs) in various benign skin disorders, in which it was not associated with KC apoptosis or proliferation, and in organotypic cultures. Furthermore, MMP-21 was induced in keratinocytes in association with increased calcium and presence of the differentiation marker filaggrin. In stably transfected A431 and HEK293 cell lines, MMP-21 increased invasion of cells but did not associate with increased apoptosis, proliferation, or epithelial-to-mesenchymal transition. Of various agents tested in HaCaT cell cultures, only retinoic acid (10(-6) M) and staurosporine (2.5 x 10(-8) M) upregulated MMP-21 mRNA and protein expression, whereas tumor promoters, hormones, or dexamethasone were without effect. Our results suggest that MMP-21 may be an important protease in the terminal differentiation of keratinocytes.
653		a MEDICINE
653		a MEDICIN
700	1	a Elomaa, Outi4 aut
700	1	a Pasonen-Seppänen, Sanna M.4 aut
700	1	a Forsberg, Sofiu Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatologi och venereologi4 aut0 (Swepub:uu)sofor168
700	1	a Ahokas, Katja4 aut
700	1	a Jeskanen, Leila4 aut
700	1	a Pärssinen, Jenita4 aut
700	1	a Tiala, Inkeri4 aut
700	1	a Rollman, Olau Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatologi och venereologi4 aut0 (Swepub:uu)olarollm
700	1	a Lohi, Jouko4 aut
700	1	a Saarialho-Kere, Ulpu4 aut
710	2	a Karolinska Institutetb Institutionen för medicinska vetenskaper4 org
773	0	t Journal of Investigative Dermatologyd : Elsevier BVg 129:1, s. 119-30q 129:1<119-30x 0022-202Xx 1523-1747
856	4	u http://www.jidonline.org/article/S0022202X15340513/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102181
856	4 8	u https://doi.org/10.1038/jid.2008.206
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:118005331

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Av författaren/redakt...: Skoog, Tiina; Elomaa, Outi; Pasonen-Seppänen ...; Forsberg, Sofi; Ahokas, Katja; Jeskanen, Leila; visa fler...; Pärssinen, Jenit ...; Tiala, Inkeri; Rollman, Ola; Lohi, Jouko; Saarialho-Kere, ...; visa färre...

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