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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 13555naa a2203529 4500 | |
| 001 | oai:DiVA.org:hj-41589 | |
| 003 | SwePub | |
| 008 | 180926s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-149020 | |
| 009 | oai:DiVA.org:su-157720 | |
| 009 | oai:prod.swepub.kib.ki.se:138360071 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-415892 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-018-04362-x2 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1490202 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1577202 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1383600712 URI |
| 040 | a (SwePub)hjd (SwePub)umud (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Davies, G.4 aut |
| 245 | 1 0 | a Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function |
| 264 | c 2018-05-29 | |
| 264 | 1 | b Nature Publishing Group,c 2018 |
| 338 | a print2 rdacarrier | |
| 500 | a Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w | |
| 520 | a General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
| 650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
| 653 | a brain | |
| 653 | a cognition | |
| 653 | a data set | |
| 653 | a genetic analysis | |
| 653 | a genome | |
| 653 | a identification method | |
| 653 | a nervous system disorder | |
| 653 | a adolescent | |
| 653 | a adult | |
| 653 | a aged | |
| 653 | a angina pectoris | |
| 653 | a Article | |
| 653 | a brain cortex | |
| 653 | a controlled study | |
| 653 | a gene expression | |
| 653 | a gene locus | |
| 653 | a genetic correlation | |
| 653 | a grip strength | |
| 653 | a heart infarction | |
| 653 | a human | |
| 653 | a hypertension | |
| 653 | a longevity | |
| 653 | a lung cancer | |
| 653 | a major clinical study | |
| 653 | a major depression | |
| 653 | a osteoarthritis | |
| 653 | a response time | |
| 653 | a vision | |
| 700 | 1 | a Lam, M.4 aut |
| 700 | 1 | a Harris, S. E.4 aut |
| 700 | 1 | a Trampush, J. W.4 aut |
| 700 | 1 | a Luciano, M.4 aut |
| 700 | 1 | a Hill, W. D.4 aut |
| 700 | 1 | a Hagenaars, S. P.4 aut |
| 700 | 1 | a Ritchie, S. J.4 aut |
| 700 | 1 | a Marioni, R. E.4 aut |
| 700 | 1 | a Fawns-Ritchie, C.4 aut |
| 700 | 1 | a Liewald, D. C. M.4 aut |
| 700 | 1 | a Okely, J. A.4 aut |
| 700 | 1 | a Ahola-Olli, A. V.4 aut |
| 700 | 1 | a Barnes, C. L. K.4 aut |
| 700 | 1 | a Bertram, L.4 aut |
| 700 | 1 | a Bis, J. C.4 aut |
| 700 | 1 | a Burdick, K. E.4 aut |
| 700 | 1 | a Christoforou, A.4 aut |
| 700 | 1 | a Derosse, P.4 aut |
| 700 | 1 | a Djurovic, S.4 aut |
| 700 | 1 | a Espeseth, T.4 aut |
| 700 | 1 | a Giakoumaki, S.4 aut |
| 700 | 1 | a Giddaluru, S.4 aut |
| 700 | 1 | a Gustavson, D. E.4 aut |
| 700 | 1 | a Hayward, C.4 aut |
| 700 | 1 | a Hofer, E.4 aut |
| 700 | 1 | a Ikram, M. A.4 aut |
| 700 | 1 | a Karlsson, R.u Karolinska Institutet4 aut |
| 700 | 1 | a Knowles, E.4 aut |
| 700 | 1 | a Lahti, J.4 aut |
| 700 | 1 | a Leber, M.4 aut |
| 700 | 1 | a Li, S.4 aut |
| 700 | 1 | a Mather, K. A.4 aut |
| 700 | 1 | a Melle, I.4 aut |
| 700 | 1 | a Morris, D.4 aut |
| 700 | 1 | a Oldmeadow, C.4 aut |
| 700 | 1 | a Palviainen, T.4 aut |
| 700 | 1 | a Payton, A.4 aut |
| 700 | 1 | a Pazoki, R.4 aut |
| 700 | 1 | a Petrovic, K.4 aut |
| 700 | 1 | a Reynolds, C. A.4 aut |
| 700 | 1 | a Sargurupremraj, M.4 aut |
| 700 | 1 | a Scholz, M.4 aut |
| 700 | 1 | a Smith, J. A.4 aut |
| 700 | 1 | a Smith, A. V.4 aut |
| 700 | 1 | a Terzikhan, N.4 aut |
| 700 | 1 | a Thalamuthu, A.4 aut |
| 700 | 1 | a Trompet, S.4 aut |
| 700 | 1 | a Van Der Lee, S. J.4 aut |
| 700 | 1 | a Ware, E. B.4 aut |
| 700 | 1 | a Windham, B. G.4 aut |
| 700 | 1 | a Wright, M. J.4 aut |
| 700 | 1 | a Yang, J.4 aut |
| 700 | 1 | a Yu, J.4 aut |
| 700 | 1 | a Ames, D.4 aut |
| 700 | 1 | a Amin, N.4 aut |
| 700 | 1 | a Amouyel, P.4 aut |
| 700 | 1 | a Andreassen, O. A.4 aut |
| 700 | 1 | a Armstrong, N. J.4 aut |
| 700 | 1 | a Assareh, A. A.4 aut |
| 700 | 1 | a Attia, J. R.4 aut |
| 700 | 1 | a Attix, D.4 aut |
| 700 | 1 | a Avramopoulos, D.4 aut |
| 700 | 1 | a Bennett, D. A.4 aut |
| 700 | 1 | a Böhmer, A. C.4 aut |
| 700 | 1 | a Boyle, P. A.4 aut |
| 700 | 1 | a Brodaty, H.4 aut |
| 700 | 1 | a Campbell, H.4 aut |
| 700 | 1 | a Cannon, T. D.4 aut |
| 700 | 1 | a Cirulli, E. T.4 aut |
| 700 | 1 | a Congdon, E.4 aut |
| 700 | 1 | a Conley, E. D.4 aut |
| 700 | 1 | a Corley, J.4 aut |
| 700 | 1 | a Cox, S. R.4 aut |
| 700 | 1 | a Dale, A. M.4 aut |
| 700 | 1 | a Dehghan, A.4 aut |
| 700 | 1 | a Dick, D.4 aut |
| 700 | 1 | a Dickinson, D.4 aut |
| 700 | 1 | a Eriksson, J. G.4 aut |
| 700 | 1 | a Evangelou, E.4 aut |
| 700 | 1 | a Faul, J. D.4 aut |
| 700 | 1 | a Ford, I.4 aut |
| 700 | 1 | a Freimer, N. A.4 aut |
| 700 | 1 | a Gao, H.4 aut |
| 700 | 1 | a Giegling, I.4 aut |
| 700 | 1 | a Gillespie, N. A.4 aut |
| 700 | 1 | a Gordon, S. D.4 aut |
| 700 | 1 | a Gottesman, R. F.4 aut |
| 700 | 1 | a Griswold, M. E.4 aut |
| 700 | 1 | a Gudnason, V.4 aut |
| 700 | 1 | a Harris, T. B.4 aut |
| 700 | 1 | a Hartmann, A. M.4 aut |
| 700 | 1 | a Hatzimanolis, A.4 aut |
| 700 | 1 | a Heiss, G.4 aut |
| 700 | 1 | a Holliday, E. G.4 aut |
| 700 | 1 | a Joshi, P. K.4 aut |
| 700 | 1 | a Kähönen, M.4 aut |
| 700 | 1 | a Kardia, S. L. R.4 aut |
| 700 | 1 | a Karlsson, Ida K.u Karolinska Institutet4 aut0 (Swepub:hj)karida |
| 700 | 1 | a Kleineidam, L.4 aut |
| 700 | 1 | a Knopman, D. S.4 aut |
| 700 | 1 | a Kochan, N. A.4 aut |
| 700 | 1 | a Konte, B.4 aut |
| 700 | 1 | a Kwok, J. B.4 aut |
| 700 | 1 | a Le Hellard, S.4 aut |
| 700 | 1 | a Lee, T.4 aut |
| 700 | 1 | a Lehtimäki, T.4 aut |
| 700 | 1 | a Li, S. -C4 aut |
| 700 | 1 | a Liu, T.4 aut |
| 700 | 1 | a Koini, M.4 aut |
| 700 | 1 | a London, E.4 aut |
| 700 | 1 | a Longstreth, W.T., Jr.4 aut |
| 700 | 1 | a Lopez, O. L.4 aut |
| 700 | 1 | a Loukola, A.4 aut |
| 700 | 1 | a Luck, T.4 aut |
| 700 | 1 | a Lundervold, A. J.4 aut |
| 700 | 1 | a Lundquist, Anders,d 1978-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik4 aut0 (Swepub:umu)anslst97 |
| 700 | 1 | a Lyytikäinen, L. -Pu Karolinska Institutet4 aut |
| 700 | 1 | a Martin, N. G.4 aut |
| 700 | 1 | a Montgomery, G. W.4 aut |
| 700 | 1 | a Murray, A. D.4 aut |
| 700 | 1 | a Need, A. C.4 aut |
| 700 | 1 | a Noordam, R.4 aut |
| 700 | 1 | a Nyberg, Lars,d 1966-u Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001 |
| 700 | 1 | a Ollier, W.4 aut |
| 700 | 1 | a Papenberg, G.u Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany4 aut |
| 700 | 1 | a Pattie, A.4 aut |
| 700 | 1 | a Polasek, O.4 aut |
| 700 | 1 | a Poldrack, R. A.4 aut |
| 700 | 1 | a Psaty, B. M.4 aut |
| 700 | 1 | a Reppermund, S.4 aut |
| 700 | 1 | a Riedel-Heller, S. G.4 aut |
| 700 | 1 | a Rose, R. J.4 aut |
| 700 | 1 | a Rotter, J. I.4 aut |
| 700 | 1 | a Roussos, P.4 aut |
| 700 | 1 | a Rovio, S. P.4 aut |
| 700 | 1 | a Saba, Y.4 aut |
| 700 | 1 | a Sabb, F. W.4 aut |
| 700 | 1 | a Sachdev, P. S.4 aut |
| 700 | 1 | a Satizabal, C. L.4 aut |
| 700 | 1 | a Schmid, M.4 aut |
| 700 | 1 | a Scott, R. J.4 aut |
| 700 | 1 | a Scult, M. A.4 aut |
| 700 | 1 | a Simino, J.4 aut |
| 700 | 1 | a Slagboom, P. E.4 aut |
| 700 | 1 | a Smyrnis, N.4 aut |
| 700 | 1 | a Soumaré, A.4 aut |
| 700 | 1 | a Stefanis, N. C.4 aut |
| 700 | 1 | a Stott, D. J.4 aut |
| 700 | 1 | a Straub, R. E.4 aut |
| 700 | 1 | a Sundet, K.4 aut |
| 700 | 1 | a Taylor, A. M.4 aut |
| 700 | 1 | a Taylor, K. D.4 aut |
| 700 | 1 | a Tzoulaki, I.4 aut |
| 700 | 1 | a Tzourio, C.4 aut |
| 700 | 1 | a Uitterlinden, A.4 aut |
| 700 | 1 | a Vitart, V.4 aut |
| 700 | 1 | a Voineskos, A. N.4 aut |
| 700 | 1 | a Kaprio, J.4 aut |
| 700 | 1 | a Wagner, M.4 aut |
| 700 | 1 | a Wagner, H.4 aut |
| 700 | 1 | a Weinhold, L.4 aut |
| 700 | 1 | a Wen, K. H.4 aut |
| 700 | 1 | a Widen, E.4 aut |
| 700 | 1 | a Yang, Q.4 aut |
| 700 | 1 | a Zhao, W.4 aut |
| 700 | 1 | a Adams, H. H. H.4 aut |
| 700 | 1 | a Arking, D. E.4 aut |
| 700 | 1 | a Bilder, R. M.4 aut |
| 700 | 1 | a Bitsios, P.4 aut |
| 700 | 1 | a Boerwinkle, E.4 aut |
| 700 | 1 | a Chiba-Falek, O.4 aut |
| 700 | 1 | a Corvin, A.4 aut |
| 700 | 1 | a De Jager, P. L.4 aut |
| 700 | 1 | a Debette, S.4 aut |
| 700 | 1 | a Donohoe, G.4 aut |
| 700 | 1 | a Elliott, P.4 aut |
| 700 | 1 | a Fitzpatrick, A. L.4 aut |
| 700 | 1 | a Gill, M.4 aut |
| 700 | 1 | a Glahn, D. C.4 aut |
| 700 | 1 | a Hägg, S.u Karolinska Institutet4 aut |
| 700 | 1 | a Hansell, N. K.4 aut |
| 700 | 1 | a Hariri, A. R.4 aut |
| 700 | 1 | a Ikram, M. K.4 aut |
| 700 | 1 | a Jukema, J. W.4 aut |
| 700 | 1 | a Vuoksimaa, E.4 aut |
| 700 | 1 | a Keller, M. C.4 aut |
| 700 | 1 | a Kremen, W. S.4 aut |
| 700 | 1 | a Launer, L.4 aut |
| 700 | 1 | a Lindenberger, U.4 aut |
| 700 | 1 | a Palotie, A.4 aut |
| 700 | 1 | a Pedersen, N. L.4 aut |
| 700 | 1 | a Pendleton, N.4 aut |
| 700 | 1 | a Porteous, D. J.4 aut |
| 700 | 1 | a Räikkönen, K.4 aut |
| 700 | 1 | a Raitakari, O. T.4 aut |
| 700 | 1 | a Ramirez, A.4 aut |
| 700 | 1 | a Reinvang, I.4 aut |
| 700 | 1 | a Rudan, I.4 aut |
| 700 | 1 | a Rujescu, D.4 aut |
| 700 | 1 | a Schmidt, R.4 aut |
| 700 | 1 | a Schmidt, H.4 aut |
| 700 | 1 | a Schofield, P. W.4 aut |
| 700 | 1 | a Schofield, P. R.4 aut |
| 700 | 1 | a Starr, J. M.4 aut |
| 700 | 1 | a Steen, V. M.4 aut |
| 700 | 1 | a Trollor, J. N.4 aut |
| 700 | 1 | a Turner, S. T.4 aut |
| 700 | 1 | a Van Duijn, C. M.4 aut |
| 700 | 1 | a Villringer, A.4 aut |
| 700 | 1 | a Weinberger, D. R.4 aut |
| 700 | 1 | a Weir, D. R.4 aut |
| 700 | 1 | a Wilson, J. F.4 aut |
| 700 | 1 | a Malhotra, A.4 aut |
| 700 | 1 | a McIntosh, A. M.4 aut |
| 700 | 1 | a Gale, C. R.4 aut |
| 700 | 1 | a Seshadri, S.4 aut |
| 700 | 1 | a Mosley, T.H., Jr.4 aut |
| 700 | 1 | a Bressler, J.4 aut |
| 700 | 1 | a Lencz, T.4 aut |
| 700 | 1 | a Deary, I. J.4 aut |
| 710 | 2 | a Karolinska Institutetb Umeå centrum för funktionell hjärnavbildning (UFBI)4 org |
| 773 | 0 | t Nature Communicationsd : Nature Publishing Groupg 9:1q 9:1x 2041-1723 |
| 856 | 4 | u https://doi.org/10.1038/s41467-018-04362-xy Fulltext |
| 856 | 4 | u https://www.nature.com/articles/s41467-018-04362-x.pdf |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1218967/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1218967/ERRATA01.pdfy errata:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-41589 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-018-04362-x |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149020 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157720 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138360071 |
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- Davies, G.
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- Luciano, M.
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- Seshadri, S.
- Mosley, T.H., Jr ...
- Bressler, J.
- Lencz, T.
- Deary, I. J.
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- Umeå University
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- Karolinska Institutet
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