WFRF:(Hermanson O)
Sökning: WFRF:(Hermanson O) > (2015-2019) > Tet3 mediates stabl...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02679naa a2200361 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:131541902 | |
| 003 | SwePub | |
| 008 | 240701s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1315419022 URI |
| 024 | 7 | a https://doi.org/10.1038/cddis.2015.1592 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bose, R4 aut |
| 245 | 1 0 | a Tet3 mediates stable glucocorticoid-induced alterations in DNA methylation and Dnmt3a/Dkk1 expression in neural progenitors |
| 264 | c 2015-06-18 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2015 |
| 520 | a Developmental exposure to excess glucocorticoids (GCs) has harmful neurodevelopmental effects, which include persistent alterations in the differentiation potential of embryonic neural stem cells (NSCs). The mechanisms, however, are largely unknown. Here, we investigated the effects of dexamethasone (Dex, a synthetic GC analog) by MeDIP-like genome-wide analysis of differentially methylated DNA regions (DMRs) in NSCs isolated from embryonic rat cortices. We found that Dex-induced genome-wide DNA hypomethylation in the NSCs in vitro. Similarly, in utero exposure to Dex resulted in global DNA hypomethylation in the cerebral cortex of 3-day-old mouse pups. Dex-exposed NSCs displayed stable changes in the expression of the DNA methyltransferase Dnmt3a, and Dkk1, an essential factor for neuronal differentiation. These alterations were dependent on Tet3 upregulation. In conclusion, we propose that GCs elicit strong and persistent effects on DNA methylation in NSCs with Tet3 playing an essential role in the regulation of Dnmt3a and Dkk1. Noteworthy is the occurrence of similar changes in Dnmt3a and Dkk1 gene expression after exposure to excess GC in vivo. | |
| 700 | 1 | a Spulber, Su Karolinska Institutet4 aut |
| 700 | 1 | a Kilian, P4 aut |
| 700 | 1 | a Heldring, Nu Karolinska Institutet4 aut |
| 700 | 1 | a Lonnerberg, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Johnsson, Au Karolinska Institutet4 aut |
| 700 | 1 | a Conti, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Hermanson, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Ceccatelli, Su Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Cell death & diseased : Springer Science and Business Media LLCg 6, s. e1793-q 6<e1793-x 2041-4889 |
| 856 | 4 | u https://www.nature.com/articles/cddis2015159.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131541902 |
| 856 | 4 8 | u https://doi.org/10.1038/cddis.2015.159 |
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