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Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography

Fager, Cecilia, 1990 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Gebäck, Tobias, 1977 (author)
Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
Hjärtstam, Johan, 1962 (author)
AstraZeneca AB
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Röding, Magnus, 1984 (author)
Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
Olsson, Anna, 1985 (author)
AstraZeneca AB
Lorén, Niklas, 1970 (author)
Chalmers tekniska högskola,Chalmers University of Technology,RISE Research Institutes of Sweden
Corswant, Christian von (author)
AstraZeneca AB
Särkkä, Aila, 1962 (author)
Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
Olsson, Eva, 1960 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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 (creator_code:org_t)
Elsevier BV, 2021
2021
English.
In: Chemical Engineering Science: X. - : Elsevier BV. - 2590-1400. ; 12
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Porous polymer coatings are used to control drug release from pharmaceutical products. The coating covers a drug core and depending on the porous structure, different drug release rates are obtained. This work presents mass transport simulations performed on porous ethyl cellulose films with different porosities. The simulations were performed on high spatial resolution 3D data obtained using a focused ion beam scanning electron microscope. The effective diffusion coefficient of water was determined using a diffusion chamber. Lattice Boltzmann simulations were used to simulate water diffusion in the 3D data. The simulated coefficient was in good agreement with the measured coefficient. From the results it was concluded that the tortuosity and constrictivity of the porous network increase with decreasing amount of added hydroxypropyl cellulose, resulting in a sharp decrease in effective diffusion. This work shows that high spatial resolution 3D data is necessary, and that 2D data is insufficient, in order to predict diffusion through the porous structure with high accuracy.

Subject headings

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Oceanografi, hydrologi och vattenresurser (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Oceanography, Hydrology and Water Resources (hsv//eng)
NATURVETENSKAP  -- Geovetenskap och miljövetenskap -- Multidisciplinär geovetenskap (hsv//swe)
NATURAL SCIENCES  -- Earth and Related Environmental Sciences -- Geosciences, Multidisciplinary (hsv//eng)
NATURVETENSKAP  -- Matematik (hsv//swe)
NATURAL SCIENCES  -- Mathematics (hsv//eng)

Keyword

Focused ion beam
Mass transport
Polymer
Soft material
Scanning electron microscopy
Three dimensional
Focused ion beam
Mass transport
Polymer
Scanning electron microscopy
Soft material
Three dimensional

Publication and Content Type

art (subject category)
ref (subject category)

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