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WFRF:(Horcajadas José A)
 

Sökning: WFRF:(Horcajadas José A) > Endometrial transcr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004406naa a2200469 4500
001oai:DiVA.org:uu-299501
003SwePub
008160722s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2995012 URI
0247 a https://doi.org/10.1016/j.rbmo.2016.03.0042 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Altmae, Signeu Competence Ctr Hlth Technol, Tartu, Estonia.;Univ Granada, Sch Med, Dept Paediat, Granada, Spain.4 aut
2451 0a Endometrial transcriptome analysis indicates superiority of natural over artificial cycles in recurrent implantation failure patients undergoing frozen embryo transfer
264 1b Elsevier BV,c 2016
338 a print2 rdacarrier
520 a Little consensus has been reached on the best protocol for endometrial preparation for frozen embryo transfer (FET). It is not known how, and to what extent, hormone supplementation in artificial cycles influences endometrial preparation for embryo implantation at a molecular level, especially in patients who have experienced recurrent implantation failure. Transcriptome analysis of 15 endometrial biopsy samples at the time of embryo implantation was used to compare two different endometrial preparation protocols, natural versus artificial cycles, for FET in women who have experienced recurrent implantation failure compared with fertile women. IPA and DAVID were used for functional analyses of differentially expressed genes. The TRANSFAC database was used to identify oestrogen and progesterone response elements upstream of differentially expressed genes. Cluster analysis demonstrated that natural cycles are associated with a better endometrial receptivity transcriptome than artificial cycles. Artificial cycles seemed to have a stronger negative effect on expression of genes and pathways crucial for endometrial receptivity, including ESR2, FSHR, LEP, and several interleukins and matrix metalloproteinases. Significant overrepresentation of oestrogen response elements among the genes with deteriorated expression in artificial cycles (P < 0.001) was found; progesterone response elements predominated in genes with amended expression with artificial cycles (P = 0.0052).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a artificial cycle
653 a endometrial receptivity
653 a frozen embryo transfer
653 a hormone response elements
653 a recurrent implantation failure
653 a unexplained female infertility
7001 a Tamm-Rosenstein, Karinu Tallinn Univ Technol, Dept Gene Technol, EE-19086 Tallinn, Estonia.4 aut
7001 a Esteban, Francisco J.u Univ Jaen, Dept Expt Biol, Jaen, Spain.4 aut
7001 a Simm, Jaaku Tallinn Univ Technol, Dept Gene Technol, EE-19086 Tallinn, Estonia.4 aut
7001 a Kolberg, Liisu Univ Tartu, Inst Comp Sci, Ulikooli 18, EE-50090 Tartu, Estonia.4 aut
7001 a Peterson, Hediu Univ Tartu, Inst Comp Sci, Ulikooli 18, EE-50090 Tartu, Estonia.;Quretec Ltd, Tartu, Estonia.4 aut
7001 a Metsis, Madisu Competence Ctr Hlth Technol, Tartu, Estonia.;Tallinn Univ, Sch Nat Sci & Hlth, EE-10120 Tallinn, Estonia.4 aut
7001 a Haldre, Kaiu West Tallinn Cent Hosp Womens Clin, Ctr Reprod Med, Tallinn, Estonia.4 aut
7001 a Horcajadas, Jose A.u Hosp Miguel Servet, Araid I CS, Zaragoza, Spain.4 aut
7001 a Salumets, Andresu Competence Ctr Hlth Technol, Tartu, Estonia.;Univ Tartu, Dept Obstet & Gynaecol, Ulikooli 18, EE-50090 Tartu, Estonia.4 aut
7001 a Stavreus-Evers, Anneliu Uppsala universitet,Obstetrik & gynekologi4 aut0 (Swepub:uu)annst384
7102 a Competence Ctr Hlth Technol, Tartu, Estonia.;Univ Granada, Sch Med, Dept Paediat, Granada, Spain.b Tallinn Univ Technol, Dept Gene Technol, EE-19086 Tallinn, Estonia.4 org
7730 t Reproductive BioMedicine Onlined : Elsevier BVg 32:6, s. 597-613q 32:6<597-613x 1472-6483x 1472-6491
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299501
8564 8u https://doi.org/10.1016/j.rbmo.2016.03.004

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