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Association between...
Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients : A Cross-Sectional Study
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- Wu, Ping-Hsun (författare)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan
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- Yi-Ting, Lin (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan
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- Wu, Pei-Yu (författare)
- Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Lab Med, Kaohsiung 807, Taiwan
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- Lee, Hei-Hwa (författare)
- Kaohsiung Med Univ Hosp, Dept Lab Med, Kaohsiung 807, Taiwan
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- Lee, Su-Chu (författare)
- Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan
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- Hung, Szu-Chun (författare)
- Tzu Chi Univ, Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Nephrol, Hualien 23142, Taiwan;Tzu Chi Univ, Sch Med, Hualien 23142, Taiwan
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- Chen, Szu-Chia (författare)
- Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 81267, Taiwan
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- Kuo, Mei-Chuan (författare)
- Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung 807, Taiwan
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- Chiu, Yi-Wen (författare)
- Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung 807, Taiwan
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(creator_code:org_t)
- 2020-01-02
- 2020
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 9:1
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Protein-bound uremic toxin is a cardiovascular (CV) risk factor for patients with end-stage renal disease. Indole-3-acetic acid (IAA) was found to be associated with CV disease but the detailed pathophysiology remains unknown. Moreover, mitogen-activated protein kinase (MAPK) signaling cascades play an important role in the pathogenesis of CV disease. Thus, we explored the association between circulating IAA levels and forty MAPK cascade associated proteins in patients undergoing hemodialysis (HD). Circulating total form IAA was quantified by mass spectrometry and forty MAPK cascade associated proteins by a proximity extension assay in 331 prevalent HD patients. Accounting for multiple testing, and in multivariable-adjusted linear regression models, circulating total form IAA levels were positively associated with stem cell factor (beta coefficient 0.13, 95% confidence interval 0.04 to 0.21, p = 0.004). A bioinformatics approach using the search tool for interactions of chemicals (STITCH) tool provided information that IAA may be involved in the regulation of cell proliferation, hematopoietic cells, and the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. The knowledge gained here can be generalized, thereby impacting the non-traditional CV risk factors in patients with kidney disease. Further in vitro work is necessary to validate the translation of the mechanistic pathways.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- uremic toxins
- indole-3-acetic acid
- proteomics
- mitogen-activated protein kinase cascade proteins
- hemodialysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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