WFRF:(Leavenworth Jianmei W.)
Sökning: WFRF:(Leavenworth Jianmei W.) > Mobilization of nat...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03450naa a2200589 4500 | |
| 001 | oai:gup.ub.gu.se/149527 | |
| 003 | SwePub | |
| 008 | 240528s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1495272 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.11121881082 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Leavenworth, Jianmei W4 aut |
| 245 | 1 0 | a Mobilization of natural killer cells inhibits development of collagen-induced arthritis. |
| 264 | c 2011-08-22 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2011 |
| 520 | a Although natural killer (NK) cells have been implicated in regulating immune responses, their ability to modulate disease development in autoimmune arthritis has not been analyzed. Here we investigate the contribution of NK cells to regulating collagen-induced arthritis, a well-characterized preclinical model of human rheumatoid arthritis. We find that the disease is induced by the combined action of two CD4(+) T helper (T(H)) subsets: follicular T(H) cells and T(H)17 cells. Both CD4(+) T(H) subsets are highly susceptible to lysis by NK cells after activation. Administration of antibody that activates NK cells through blockade of its inhibitory CD94/NKG2A receptor allows enhanced elimination of pathogenic follicular T(H) and T(H)17 cells and arrest of disease progression. These results suggest that antibody-dependent enhancement of NK activity may yield effective, previously undescribed therapeutic approaches to this autoimmune disorder. | |
| 650 | 7 | a LANTBRUKSVETENSKAPERx Veterinärmedicinx Klinisk vetenskap0 (SwePub)403032 hsv//swe |
| 650 | 7 | a AGRICULTURAL SCIENCESx Veterinary Sciencex Clinical Science0 (SwePub)403032 hsv//eng |
| 653 | a Animals | |
| 653 | a Arthritis | |
| 653 | a Experimental | |
| 653 | a etiology | |
| 653 | a prevention & control | |
| 653 | a Cell Communication | |
| 653 | a Killer Cells | |
| 653 | a Natural | |
| 653 | a physiology | |
| 653 | a Mice | |
| 653 | a Mice | |
| 653 | a Inbred C57BL | |
| 653 | a NK Cell Lectin-Like Receptor Subfamily C | |
| 653 | a physiology | |
| 653 | a NK Cell Lectin-Like Receptor Subfamily D | |
| 653 | a physiology | |
| 653 | a Th1 Cells | |
| 653 | a physiology | |
| 653 | a Th17 Cells | |
| 653 | a physiology | |
| 700 | 1 | a Wang, Xiaoyang,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xwanxi |
| 700 | 1 | a Wenander, Carola Schellack4 aut |
| 700 | 1 | a Spee, Pieter4 aut |
| 700 | 1 | a Cantor, Harvey4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 108:35, s. 14584-9q 108:35<14584-9x 1091-6490 |
| 773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 108:35, s. 14584-9q 108:35<14584-9x 0027-8424 |
| 856 | 4 | u http://www.pnas.org/content/108/35/14584.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/149527 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.1112188108 |
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