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Alterations in Gene Expression During Radiation-Induced Mitotic Catastrophe in He La Hep2 Cells
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- Lindgren, Theres (författare)
- Umeå universitet,Klinisk immunologi
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- Stigbrand, Torgny (författare)
- Umeå universitet,Klinisk immunologi
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- Johansson, Lennart (författare)
- Umeå universitet,Radiofysik
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- (creator_code:org_t)
- INT INST ANTICANCER RESEARCH, 2014
- 2014
- Engelska.
- Ingår i: Anticancer Research. - : INT INST ANTICANCER RESEARCH. - 0250-7005 .- 1791-7530. ; 34:8, s. 3875-3880
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Aim: To explore kinetic changes in the gene expression profile during radiation-induced mitotic catastrophes. Materials and Methods: Gene expression changes were measured in HPV-infected HeLa Hep2 tumor cells following exposure to 5 Gy of ionizing radiation (Co-60). Signaling pathways were explored and correlated to the biological responses linked to mitotic catastrophe. Results: Following irradiation a transient G(2)-arrest was induced. Anaphase bridge formation and centrosome hyperamplification was observed. These phenotypical changes correlated well with the observed gene expression changes. Genes with altered expression were found to be involved in mitotic processes as well as G(2)- and spindle assembly checkpoints. Also centrosome-associated genes displayed an increased expression. Conclusion: This study elucidates specific characteristics in the altered gene expression pattern induced by irradiation, which can be correlated to the events of mitotic catastrophe in HeLa Hep2 cells. Therapeutic strategies modulating these alterations might potentiate future therapy and enhance tumor cell killing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Radiation
- cell cycle checkpoint
- cell death
- mitotic catastrophe
- gene expression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Riklund, Katrine
- Eriksson, David
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